naa a22 4500 510786278 CHVBK 20180411083303.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12603-013-0347-6 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0347-6 Berraho M. Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy, Fez — Morocco. Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France aut Dyspnea: A strong independent factor for long-term mortality in the elderly [Elektronische Daten] [M. Berraho] Objective: To determine the association between dyspnea at entry into the PAQUID cohort and 13-year mortality, taking into consideration BMI and other mortality-related factors. Methods: Design: Longitudinal study. Setting: In Dordogne and Gironde, South Western France. Subjects: A total of 3646 French community dwellers aged 65 years old and over from the PAQUID study were included. Main outcome measures: dyspnea measured on 5-grades scale, mortality measured over 13 years of follow-up. Adjustment variables: age, gender, BMI (kg/m2), antecedent of ischemic heart disease, antecedent of stroke, hypertension, smoking history and diabetes. Results: The study sample included 3646 subjects out of whom 54.11% died at 13 years of follow-up, 57.3% of participants were women and mean age was 75.3 (SD 6.8) years. Univariate analysis showed that dyspnea was associated with 13-year mortality. Death occurred in 45.6% of non-dyspneic subjects, 51.8% in those with level 1 of dyspnea, 65.6% in level 2 and 80.6% in level 3 and 4 (P<10−4). The median survival was at 13.26 (SD 0.20) years for level-0 of dyspnea, 12.33 (SD 0.31) years for level-1 of dyspnea, 9.28 (SD 0.44) years for level-2 and 6.43 (SD 0.45) years for level-3 and 4 (P=10−3). In the multivariate analysis, the risk of mortality for level1 compared to level-0 was HR=1.13 (CI95%=[1.01-1.26]); this risk increases to HR=1.42 (CI95%=[1.25-1.63]) for level-2 and to HR=1.90 (CI95%=[1.61-2.25]) for level-3 and 4. Conclusion: These findings suggest that the relationship between long-term mortality and dyspnea is strong, consistent and independent of other covariates in the elderly. Serdi and Springer-Verlag France, 2013 Dyspnea nationallicence mortality nationallicence elderly nationallicence morbidity nationallicence ageing nationallicence cohort nationallicence The journal of nutrition, health & aging Springer Paris 17/10(2013-12-01), 908-912 1279-7707 17:10<908 2013 17 12603 https://doi.org/10.1007/s12603-013-0347-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0347-6 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Berraho M. Department of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy, Fez — Morocco. Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000, Bordeaux, France aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/10(2013-12-01), 908-912 1279-7707 17:10<908 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer