naa a22 4500 510786421 CHVBK 20180411083303.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12603-012-0397-1 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0397-1 Body mass index, lifestyles, physical performance and cognitive decline: The "Treviso Longeva (Trelong)” study [Elektronische Daten] [Maurizio Gallucci, S. Mazzuco, F. Ongaro, E. Di Giorgi, P. Mecocci, M. Cesari, D. Albani, G. Forloni, E. Durante, G. Gajo, A. Zanardo, M. Siculi, L. Caberlotto, C. Regini] Objectives: The relative contributions of risk factors, as body mass index (BMI), depression, chronic diseases, smoking, and lifestyles (as physical and performance activity, social contacts and reading habit) to cognitive decline in the elderly are unclear. We explored these variables in relation to 7-year cognitive decline in long-lived Italian elderly. Design: Secondary data analysis of a longitudinal study of a representative, age-stratified, population sample. Setting: The TREVISO LONGEVA (TRELONG) Study, in Treviso, Italy. Participants: 120 men and 189 women, age 77 years and older (mean age 80.2 ± 6.9 years) survivors after seven years of follow up. Measurements: Cognitive decline measured as difference between Mini-Mental State Examination (MMSE) score in 2003 and in 2010; Body mass index (BMI), handgrip, Short Physical Performance Battery (SPPB) score, social contacts, reading habit, sight, hearing, schooling, mediterranean diet and multiple clinical and survey data recorded at baseline in 2003. Results: In separate univariate analyses, age, SPPB score < 5, depressive symptoms (GDS) and more comorbidities (CCI) were associated with greater cognitive decline. Otherwise higher BMI, higher handgrip, reading habit, non-deteriorated sight and hearing, and schooling were protective. In a final multivariate model, age and higher BMI were associated with greater cognitive decline while reading habits was protective. SPPB score < 5 tends, though weakly, to be associated with greater cognitive decline. These associations remained with multivariate adjustment for gender, schooling, Charlson co-morbidity index (CCI) and baseline MMSE. Conclusion: Age and higher baseline BMI, independent of gender, and other confounding factors, are risk factors for cognitive decline. Reading habit plays a protective role seven years later among northern Italian adults aged 70 years or older. Low physical performance tends, though weakly, to be associated with greater cognitive decline. Serdi and Springer-Verlag France, 2013 Cognitive decline nationallicence body mass index (BMI) nationallicence physical performance nationallicence lifestyles nationallicence Gallucci Maurizio Cognitive Impairment Centre, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut Mazzuco S. Department of Statistics University of Padova, Via Cesare Battisti, 241, 35121, Padova, Italy aut Ongaro F. Department of Statistics University of Padova, Via Cesare Battisti, 241, 35121, Padova, Italy aut Di Giorgi E. Territorial Health Services of Treviso, Via Isola di Mezzo, 37, 31100, Treviso, Italy aut Mecocci P. Institute of Gerontology and Geriatrics, University Hospital, 06156, Perugia, Italy aut Cesari M. Institut du Vieillissement, Université de Toulouse, 37 Allées Jules Guesde, 31000, Toulouse, France aut Albani D. Department of Neuroscience, "Mario Negri” Institute for Pharmacological Research, via La Masa, 19, 20156, Milan, Italy aut Forloni G. Department of Neuroscience, "Mario Negri” Institute for Pharmacological Research, via La Masa, 19, 20156, Milan, Italy aut Durante E. Transfusional Medicine Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut Gajo G. Transfusional Medicine Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut Zanardo A. Clinical Pathology Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut Siculi M. Clinical Pathology Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut Caberlotto L. Clinical Pathology Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut Regini C. FORGEI, Interdisciplinary Geriatric Research Foundation, Viale Trento Trieste, 19, 31100, Treviso, Italy aut The journal of nutrition, health & aging Springer-Verlag 17/4(2013-04-01), 378-384 1279-7707 17:4<378 2013 17 12603 https://doi.org/10.1007/s12603-012-0397-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0397-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gallucci Maurizio Cognitive Impairment Centre, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Mazzuco S. Department of Statistics University of Padova, Via Cesare Battisti, 241, 35121, Padova, Italy aut NATIONALLICENCE 700 1- Ongaro F. Department of Statistics University of Padova, Via Cesare Battisti, 241, 35121, Padova, Italy aut NATIONALLICENCE 700 1- Di Giorgi E. Territorial Health Services of Treviso, Via Isola di Mezzo, 37, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Mecocci P. Institute of Gerontology and Geriatrics, University Hospital, 06156, Perugia, Italy aut NATIONALLICENCE 700 1- Cesari M. Institut du Vieillissement, Université de Toulouse, 37 Allées Jules Guesde, 31000, Toulouse, France aut NATIONALLICENCE 700 1- Albani D. Department of Neuroscience, "Mario Negri” Institute for Pharmacological Research, via La Masa, 19, 20156, Milan, Italy aut NATIONALLICENCE 700 1- Forloni G. Department of Neuroscience, "Mario Negri” Institute for Pharmacological Research, via La Masa, 19, 20156, Milan, Italy aut NATIONALLICENCE 700 1- Durante E. Transfusional Medicine Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Gajo G. Transfusional Medicine Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Zanardo A. Clinical Pathology Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Siculi M. Clinical Pathology Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Caberlotto L. Clinical Pathology Department, General Hospital of Treviso, Piazza Ospedale, 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Regini C. FORGEI, Interdisciplinary Geriatric Research Foundation, Viale Trento Trieste, 19, 31100, Treviso, Italy aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/4(2013-04-01), 378-384 1279-7707 17:4<378 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer