naa a22 4500 510786456 CHVBK 20180411083304.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12603-013-0036-5 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0036-5 Capacity to consent to biomedical research's evaluation among older cognitively impaired patients. A study to validate the University of California Brief Assessment of Capacity to Consent questionnaire in French among older cognitively impaired patients [Elektronische Daten] [Emmanuelle Duron, M. Boulay, Jean-Sébastien Vidal, Jamila El Bchiri, Marie-Laure Fraisse, Anne Rigaud, Laurence Hugonot-Diener] Context: Some studies have highlighted the difficulty for physicians to evaluate patient's ability to consent to bio-medical research in the elderly population. The University of California Brief Assessment of Capacity to Consent (UBACC) is a rapid questionnaire to assess the ability to consent, previously validated among schizophrenic patients. Objective: To evaluate the accuracy of the UBACC scale, French version, to determine the capacity to consent to biomedical studies of older people with normal cognition, mild cognitive impairment (MCI) or Alzheimer Disease (AD). Design: A prospective validation study between September 2008 to November 2011. Setting: A Memory clinic. Patients: We included 61 subjects in a memory clinic who had already consented to participate to a biomedical research and had signed a consent form. Those subjects, who had memory impairment, had a comprehensive neuro-psychological (including Mini Mental State Examination (MMSE)/30), clinical, biological assessment and brain imagery during day-care hospital. They were classified as MCI or AD patients. Control group included patients' caregivers without memory complaints and a normal comprehensive neuro-psychological assessment. Intervention and measurements: The consent form was once again explained to the subjects by a physician who subjectively evaluated if subjects had understood the study. Then, the 10 questions of the French version of the UBACC scale (max score 20) were asked to the participants. This scale evaluates the understanding of the study's aim, risks and benefits. A comparison was made between subjective assessment and the UBACC score. Results: The physician considered that 18/61 patients (2 MCI and 16 AD) had not understood. These ones had a lower UBACC score (Score/20 (SD) [range]: 7.56 (3.03) [0-12] versus 17.72 (2.68) [13-28], p<0.001), a lower MMSE (Score/30 (SD): 21.1 (5.9) versus 27.3 (2.9); p<0.001) and were older (age (years old) 80.8 versus 76.6. p<0.0001) compared to those who had understood. Moreover, all the patients who had not understood had an UBACC score ≤ 12. The administration time was accurate in this population (<10 minutes). Conclusion: The UBACC scale, in its French version, was accurate to assess capacity to consent in an older, cognitively impaired population. Serdi and Springer-Verlag France, 2013 Duron Emmanuelle groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut Boulay M. groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut Vidal Jean-Sébastien groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut El Bchiri Jamila E-mail: jamila_elbchiri@yahoo.fr aut Fraisse Marie-Laure Merck Serono-Geneva, Geneva, Switzerland aut Rigaud Anne groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut Hugonot-Diener Laurence groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut The journal of nutrition, health & aging Springer-Verlag 17/4(2013-04-01), 385-389 1279-7707 17:4<385 2013 17 12603 https://doi.org/10.1007/s12603-013-0036-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0036-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duron Emmanuelle groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut NATIONALLICENCE 700 1- Boulay M. groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut NATIONALLICENCE 700 1- Vidal Jean-Sébastien groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut NATIONALLICENCE 700 1- El Bchiri Jamila E-mail: jamila_elbchiri@yahoo.fr aut NATIONALLICENCE 700 1- Fraisse Marie-Laure Merck Serono-Geneva, Geneva, Switzerland aut NATIONALLICENCE 700 1- Rigaud Anne groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut NATIONALLICENCE 700 1- Hugonot-Diener Laurence groupe hospitalier Paris-centre. Broca Hospital, Department of Geriatrics, AP-HP, 54-56 rue Pascal, 75013, Paris, France aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/4(2013-04-01), 385-389 1279-7707 17:4<385 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer