naa a22 4500 510786677 CHVBK 20180411083304.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12603-013-0023-x doi (NATIONALLICENCE)springer-10.1007/s12603-013-0023-x Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea [Elektronische Daten] [P. Chen, C. Guo, C. Tseng, K. Wang, Po-Jen Liu] Background: Obstructive sleep apnea (OSA) is associated with increased oxidative stress. Certain essential trace minerals have shown to play an important role in the maintenance of redox homeostasis. We determined the concentrations of trace minerals in OSA patients and assessed their relationships to OSA severity as indicated by the apnea/hypopnea index (AHI). Methods: We enrolled 44 patients with newly diagnosed mild to moderate OSA and 20 without OSA. The following parameters were measured: polysomnographic values of nocturnal sleep; plasma trace minerals zinc (Zn), copper (Cu), iron (Fe), and erythrocyte selenium (Se); oxidative stress status; and plasma high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α). Results: Compared to controls matched for age, gender, and body mass index, OSA patients had lower concentrations of plasma Zn and erythrocyte Se and higher plasma concentrations of Cu and Fe. OSA patients had significantly higher plasma concentrations of hs-CRP, TNF-α, and malondialdehyde (MDA), and lower erythrocyte antioxidant enzyme glutathione peroxidase (GPx) and superoxide dismutase activities. Significant differences in all the above parameters were also found in patients with moderate OSA compared to those with mild OSA. Furthermore, AHI values correlated significantly with neck circumference, GPx activity, and MDA, hs-CRP, and TNF-α concentrations in OSA patients. AHI values were also negatively associated with concentrations of plasma Zn and erythrocyte Se, but were positively linked to plasma concentrations of Fe and Cu. Conclusions: Abnormal concentrations of these trace minerals may reflect oxidative damage and inflammatory response, thus increasing the severity of OSA. Serdi and Springer-Verlag France, 2013 Trace minerals nationallicence oxidative stress nationallicence inflammation nationallicence obstructive sleep apnea nationallicence Chen P. Biomedical Nutrition & Micro-Nutrition Labs, Institute of Biomedical Nutrition, Hung Kuang University, 433, Taichung, Taiwan, Republic of China aut Guo C. Biomedical Nutrition & Micro-Nutrition Labs, Institute of Biomedical Nutrition, Hung Kuang University, 433, Taichung, Taiwan, Republic of China aut Tseng C. Nutrition Room, Yuan-Rung General Hospital, 510, Changhua, Taiwan, Republic of China aut Wang K. Department of Otolaryngology, Cheng-Ching Hospital, Taiwan Boulevard, 407, Taichung, Taiwan, Republic of China aut Liu Po-Jen Department of Otolaryngology & Nutrition and Naturopathic center, Cheng-Ching Hospital, Taiwan Boulevard, 407, Taichung, Taiwan, Republic of China aut The journal of nutrition, health & aging Springer Paris 17/8(2013-10-01), 639-644 1279-7707 17:8<639 2013 17 12603 https://doi.org/10.1007/s12603-013-0023-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0023-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen P. Biomedical Nutrition & Micro-Nutrition Labs, Institute of Biomedical Nutrition, Hung Kuang University, 433, Taichung, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Guo C. Biomedical Nutrition & Micro-Nutrition Labs, Institute of Biomedical Nutrition, Hung Kuang University, 433, Taichung, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Tseng C. Nutrition Room, Yuan-Rung General Hospital, 510, Changhua, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Wang K. Department of Otolaryngology, Cheng-Ching Hospital, Taiwan Boulevard, 407, Taichung, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Liu Po-Jen Department of Otolaryngology & Nutrition and Naturopathic center, Cheng-Ching Hospital, Taiwan Boulevard, 407, Taichung, Taiwan, Republic of China aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/8(2013-10-01), 639-644 1279-7707 17:8<639 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer