naa a22 4500 510786758 CHVBK 20180411083305.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12603-013-0006-y doi (NATIONALLICENCE)springer-10.1007/s12603-013-0006-y Micronutrients-incorporated calcium phosphate particles with protective effect on osteoporotic bone tissue [Elektronische Daten] [X. Chen, L. Zhang, X. Yang, Z. Li, X. Sun, M. Lin, G. Yang, Zongru Gou] Background: Supplementation of individual micronutrient is inadequate for maintaining bone function because single micronutrient can not contribute significantly a positive remodeling balance. Objective: We developed the highly integrated, stably dietary multi-micronutrients with good bioavailability and low adverse effect on the improvement of bone consolidation in osteoporosis. Methods: The trace element-codoped calcium phosphate (teCaP) particles were prepared in the modified body fluid and carefully evaluated. Rats, aged 3 months, were ovariectomized and when 6 month intervened with the conditioned, low, moderate, and high teCaP diets. Results: The teCaP particles showed highly dissolvable in stomach juice-mimicing acidic solutions. Three months after intervention, the body weight increase showed remarkable differences among the low teCaP diet (∼52 g), moderate teCaP diet (∼34 g) and high teCaP diet (∼23 g) group. In particular, the intake of moderate teCaP greatly improved the retention of trace elements in femural bone for better protection against the skeletal weakening, and resulted in a significant increase of bone mineral density (104.06%) in comparison with the conventional high calcium plus vitamin D3 diet (Control group). Conclusions: These investigations improve our understanding of micronutrient retention on bone consolidation in osteoporotic bone tissue, and also provide new mild wet-chemical approach to prepare potent nutritionally effective edible complements to synergistically relieve bone degeneration and prevent osteoporosis. Serdi and Springer-Verlag France, 2013 Micronutrient nationallicence trace element nationallicence calcium phosphate nationallicence dietary supplement nationallicence antiosteoporosis nationallicence Chen X. Zhejiang-California International Nanosystems Institute, Zhejiang University, 310029, Hangzhou, China aut Zhang L. Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, 325200, Ruian, China aut Yang X. Zhejiang-California International Nanosystems Institute, Zhejiang University, 310029, Hangzhou, China aut Li Z. Zhejiang-California International Nanosystems Institute, Zhejiang University, 310029, Hangzhou, China aut Sun X. Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, 325200, Ruian, China aut Lin M. Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, 325200, Ruian, China aut Yang G. Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, 325200, Ruian, China aut Gou Zongru Zhejiang-California International Nanosystems Institute, Zhejiang University, 310029, Hangzhou, China aut The journal of nutrition, health & aging Springer-Verlag 17/5(2013-05-01), 426-433 1279-7707 17:5<426 2013 17 12603 https://doi.org/10.1007/s12603-013-0006-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0006-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen X. Zhejiang-California International Nanosystems Institute, Zhejiang University, 310029, Hangzhou, China aut NATIONALLICENCE 700 1- Zhang L. Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, 325200, Ruian, China aut NATIONALLICENCE 700 1- Yang X. Zhejiang-California International Nanosystems Institute, Zhejiang University, 310029, Hangzhou, China aut NATIONALLICENCE 700 1- Li Z. Zhejiang-California International Nanosystems Institute, Zhejiang University, 310029, Hangzhou, China aut NATIONALLICENCE 700 1- Sun X. Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, 325200, Ruian, China aut NATIONALLICENCE 700 1- Lin M. Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, 325200, Ruian, China aut NATIONALLICENCE 700 1- Yang G. Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, 325200, Ruian, China aut NATIONALLICENCE 700 1- Gou Zongru Zhejiang-California International Nanosystems Institute, Zhejiang University, 310029, Hangzhou, China aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/5(2013-05-01), 426-433 1279-7707 17:5<426 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer