naa a22 4500 510786766 CHVBK 20180411083305.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12603-012-0418-0 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0418-0 Serum 25-hydroxyvitamin D levels and the risk of depression: A systematic review and meta-analysis [Elektronische Daten] [Sang-Yhun Ju, Y. Lee, S. Jeong] Objective: No quantitative systematic review or meta-analysis of population-based epidemiological studies has been conducted to assess the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of depression. This study aimed to summarize the current evidence from cross-sectional and prospective cohort studies that have evaluated the association between 25(OH)D levels and the risk of depression. Methods: Relevant studies were identified by systematically searching the PubMed, EMBASE, Web of Science, and PsycINFO databases through April 2012. Cross-sectional and cohort studies that reported adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association of interest were included. The reported risk estimates for 25(OH)D categories were recalculated, employing a comprehensive trend estimation from summarized dose-response data. A pooled OR was calculated separately for cross-sectional and cohort studies using random-effects models. Results: In the meta-analysis, 25(OH)D levels were significantly inversely associated with depression in 5 of 11 case-control studies and 2 of 5 cohort studies. The pooled estimate of the adjusted OR of depression in 11 cross-sectional studies (n = 43,137) was 0.96 (95% CI = 0.94-0.99, I2 = 63%) for a 10 ng/ml increase in 25(OH)D levels. The 5 included cohort studies comprised 12,648 participants, primarily elderly individuals, whose serum 25(OH)D levels were measured, and 2,663 experienced depression events during follow-up. The pooled adjusted OR of depression was 0.92 (95% CI = 0.87-0.98, I2 = 50%) for a 10 ng/ml increase in 25(OH)D levels. Conclusions: Our results indicate an inverse association between serum 25(OH)D levels and the risk of depression. Further studies are warranted to establish whether this association is causal. Serdi and Springer-Verlag France, 2012 Depression nationallicence 25-hydroxyvitamin D nationallicence dose-response meta-analysis nationallicence elderly nationallicence Ju Sang-Yhun Department of Family Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea aut Lee Y. Department of Family Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea aut Jeong S. Medical Library, Yeouido St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea aut The journal of nutrition, health & aging Springer-Verlag 17/5(2013-05-01), 447-455 1279-7707 17:5<447 2013 17 12603 https://doi.org/10.1007/s12603-012-0418-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0418-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ju Sang-Yhun Department of Family Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Y. Department of Family Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Jeong S. Medical Library, Yeouido St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/5(2013-05-01), 447-455 1279-7707 17:5<447 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer