naa a22 4500 510786812 CHVBK 20180411083305.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12603-012-0419-z doi (NATIONALLICENCE)springer-10.1007/s12603-012-0419-z Low vitamin and carotenoid levels are related to cerebral white matter lesions [Elektronische Daten] [Y. Ohshima, Toshiki Mizuno, K. Yamada, S. Matsumoto, Y. Nagakane, M. Kondo, N. Kuriyama, T. Miyazaki, K. Takeda, T. Nishimura, M. Nakagawa, K. Ozasa, Y. Watanabe] Objectives: Purpose: To determine the effects of vitamins and carotenoids on brain white matter lesions (WMLs), we examined the associations between WMLs with vitamin and carotenoid levels in Japanese middle-aged and elderly subjects. Subjects and methods: Four-hundred and sixty-nine healthy participants (male = 317; female = 152) that underwent medical examinations were examined. Deep white matter lesions (DWLs) were detected via magnetic resonance imaging (MRI) in 39 subjects. We evaluated the effects of vitamin and carotenoid levels on DWLs via logistic regression analysis. Results: Lower gamma-tocopherol levels were significantly associated with DWLs in all subjects. While lower gamma-tocopherol and vitamin C levels were significantly associated with DWLs in males, lower delta-tocopherol levels were associated with DWLs in females. The associations between DWLs and lower gamma- and delta-tocopherol and vitamin C levels were independent of age, hypertension, or smoking. However, the associations between DWLs and lower alfatocopherol were not significant following adjustments for smoking. Conclusion: Lower carotenoid and vitamin levels were independently associated with cerebral DWLs in Japanese subjects. Serdi and Springer-Verlag France, 2012 Vitamin nationallicence carotenoid nationallicence magnetic resonance imaging nationallicence white matter lesion nationallicence cerebral ischemia nationallicence Ohshima Y. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Mizuno Toshiki Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Yamada K. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Matsumoto S. Kyoto Industrial Health Association, Kyoto, Japan aut Nagakane Y. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Kondo M. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Kuriyama N. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Miyazaki T. Kyoto Industrial Health Association, Kyoto, Japan aut Takeda K. Kyoto Industrial Health Association, Kyoto, Japan aut Nishimura T. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Nakagawa M. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Ozasa K. Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Watanabe Y. Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan aut The journal of nutrition, health & aging Springer-Verlag 17/5(2013-05-01), 456-460 1279-7707 17:5<456 2013 17 12603 https://doi.org/10.1007/s12603-012-0419-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0419-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohshima Y. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Mizuno Toshiki Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamada K. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Matsumoto S. Kyoto Industrial Health Association, Kyoto, Japan aut NATIONALLICENCE 700 1- Nagakane Y. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Kondo M. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Kuriyama N. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Miyazaki T. Kyoto Industrial Health Association, Kyoto, Japan aut NATIONALLICENCE 700 1- Takeda K. Kyoto Industrial Health Association, Kyoto, Japan aut NATIONALLICENCE 700 1- Nishimura T. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Nakagawa M. Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Ozasa K. Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Watanabe Y. Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/5(2013-05-01), 456-460 1279-7707 17:5<456 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer