naa a22 4500 510786855 CHVBK 20180411083305.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12603-012-0372-x doi (NATIONALLICENCE)springer-10.1007/s12603-012-0372-x A probiotics-containing biscuit modulates the intestinal microbiota in the elderly [Elektronische Daten] [S. Rampelli, M. Candela, M. Severgnini, E. Biagi, S. Turroni, M. Roselli, P. Carnevali, L. Donini, P. Brigidi] Objectives: Evaluation of the impact of a biscuit containing the probiotics Bifidobacterium longum Bar33 and Lactobacillus helveticus Barl3 on the intestinal microbiota in the elderly. Design: Randomized double-blind placebo-controlled trial. Participants: Thirty-two elderly volunteers living in Italy. The group was composed of 19 women and 13 men aged between 71 and 88 years (mean 76). Intervention: Subjects were randomized in two groups consuming one dose of the probiotics-containing biscuit or placebo once a day for 30 days. Measurements: For each subject the intestinal microbiota was characterized using the phylogenetic microarray platform HTF-Microbi. Array before and after intervention. Results: Our data demonstrated that one-month consumption of a probiotics-containing biscuit was effective in redressing some of the age-related dysbioses of the intestinal microbiota. In particular, the probiotic treatment reverted the age-related increase of the opportunistic pathogens Clostridium cluster XI, Clostridium difficile, Clostridium perfringens, Enterococcus faecium and the enteropathogenic genus Campylobacter. Conclusion: The present study opens the way to the development of elderly-tailored probiotic-based functional foods to counteract the age-related dysbioses of the intestinal microbiota. Serdi and Springer-Verlag France, 2013 Intestinal microbiota nationallicence dysbioses nationallicence aging nationallicence inflammaging nationallicence probiotics nationallicence Rampelli S. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut Candela M. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut Severgnini M. Institute of Biomedical Technologies — Italian National Research Council, Milan, Italy aut Biagi E. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut Turroni S. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut Roselli M. Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Roma, Italy aut Carnevali P. R&D Food Microbiology & Bioprocess Research, Barilla G&R f.lli SpA, Parma, Italy aut Donini L. Medical Physiopathology, Food Science and Endocrinology Section, Food Science and Human Nutrition Research Unit, Sapienza University, Rome, Italy aut Brigidi P. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut The journal of nutrition, health & aging Springer-Verlag 17/2(2013-02-01), 166-172 1279-7707 17:2<166 2013 17 12603 https://doi.org/10.1007/s12603-012-0372-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0372-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rampelli S. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Candela M. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Severgnini M. Institute of Biomedical Technologies — Italian National Research Council, Milan, Italy aut NATIONALLICENCE 700 1- Biagi E. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Turroni S. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Roselli M. Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Roma, Italy aut NATIONALLICENCE 700 1- Carnevali P. R&D Food Microbiology & Bioprocess Research, Barilla G&R f.lli SpA, Parma, Italy aut NATIONALLICENCE 700 1- Donini L. Medical Physiopathology, Food Science and Endocrinology Section, Food Science and Human Nutrition Research Unit, Sapienza University, Rome, Italy aut NATIONALLICENCE 700 1- Brigidi P. Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/2(2013-02-01), 166-172 1279-7707 17:2<166 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer