naa a22 4500 510786987 CHVBK 20180411083305.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12603-012-0088-y doi (NATIONALLICENCE)springer-10.1007/s12603-012-0088-y Parathyroid hormone response to severe vitamin D deficiency is sex associated: An observational study of 571 hip fracture inpatients [Elektronische Daten] [Marco Di Monaco, C. Castiglioni, F. Vallero, R. Di Monaco, R. Tappero] Objectives: To investigate the association between sex and parathyroid hormone response to severe vitamin D deficiency after hip fracture. Design: Cross-sectional study. Setting: Rehabilitation hospital in Italy. Participants: 571 consecutive inpatients with hip fracture and severe vitamin D deficiency (serum 25-hydroxyvitamin D < 12ng/ml), without hypercalcemia or estimated glomerular filtration rate (GFR) < 15ml/min. Measurements: In each patient we assessed PTH (by two-site chemiluminescent enzyme-labelled immunometric assay), 25-hydroxyvitamin D (by immunoenzymatic assay), albumin-adjusted total calcium, phosphate, magnesium, and creatinine 21.3 ± 6.1 (mean ± SD) days after fracture occurrence. Functional level was assessed using the Barthel index. PTH response to vitamin D deficiency was classified as either secondary hyperparathyroidism (serum PTH >75pg/ml) or functional hypoparathyroidism, i.e., inappropriate normal levels of PTH (≤75pg/ml). Results: Among the 571 patients, 336 (59%) had functional hypoparathyroidism, whereas 235 (41%) had secondary hyperparathyroidism. PTH status was significantly different between sexes (p=0.003): we found functional hypoparathyroidism in 61% of women and 43% of men (secondary hyperparathyroidism in 39% of women and 57% of men). The significance of the between-sex difference was maintained after adjustment for age, estimated GFR, phosphate, albumin-adjusted total calcium, albumin, Barthel index scores, 25-hydroxyvitamin D, and hip fracture type (either cervical or trochanteric). The adjusted odds ratio was 1.85 (95%CI from 1.09 to 3.13; p=0.023). Conclusions: Data shows that PTH response to vitamin D deficiency was sex-associated following a fracture of the hip. The higher prevalence of secondary hyperparathyroidism may play a role in the known prognostic disadvantage found in hip-fracture men. Serdi and Springer Verlag France, 2013 Hip fracture nationallicence parathyroid hormone nationallicence secondary hyperparathyroidism nationallicence vitamin D nationallicence Di Monaco Marco Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy aut Castiglioni C. Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy aut Vallero F. Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy aut Di Monaco R. Department of Social Science, University, via Sant'Ottavio 50, 10124, Torino, Italy aut Tappero R. Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy aut The journal of nutrition, health & aging Springer-Verlag 17/2(2013-02-01), 180-184 1279-7707 17:2<180 2013 17 12603 https://doi.org/10.1007/s12603-012-0088-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0088-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Di Monaco Marco Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy aut NATIONALLICENCE 700 1- Castiglioni C. Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy aut NATIONALLICENCE 700 1- Vallero F. Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy aut NATIONALLICENCE 700 1- Di Monaco R. Department of Social Science, University, via Sant'Ottavio 50, 10124, Torino, Italy aut NATIONALLICENCE 700 1- Tappero R. Osteoporosis Research Center, Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/2(2013-02-01), 180-184 1279-7707 17:2<180 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer