naa a22 4500 510786995 CHVBK 20180411083305.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12603-012-0090-4 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0090-4 Evaluation of vitamin D medicines and dietary supplements and the physicochemical analysis of selected formulations [Elektronische Daten] [Sanjay Garg, D. Sabri, J. Kanji, P. Rakkar, Y. Lee, N. Naidoo, D. Svirskis] Context: Vitamin D is purported to offer wide ranging and numerous health benefits leading to increased interest from manufacturers of medicines and dietary supplements. Elderly patients frequently require vitamin D supplementation due to reduced sun exposure and dietary intake. There are ever increasing numbers of vitamin D formulations in the global market. However, due to a lack of regulatory restrictions for some of these products the quality of these dosage forms can be of some concern. Objectives: To study vitamin D formulations available in the global market and evaluate physic-chemical properties of selected formulations from the New Zealand market. Method: The first component of this study consisted of a search for different vitamin D formulations available in selected countries. The second component of the study involved assaying selected vitamin D formulations available in New Zealand. Vitamin D was extracted from capsule, tablet and emulsion formulations and quantified using a validated High Performance Liquid Chromatography (HPLC) method. Results: Of the 14 analysed formulations, only 60% were within 100+10 % of the label claim. The two registered, prescription formulations available exhibited vitamin D levels of 90+4% and 97±2% of the labeled amount, while non-registered, non-prescription dietary supplements had vitamin D levels ranging from 8±2% to 201±29% of the labeled amount. Conclusions: Dietary supplements do not require strict regulation and showed a large variation in the percentage label claim of vitamin D. Prescription formulations which are more strictly regulated gave content values within standard acceptance ranges. Vitamin D has proven health benefits and also the potential to cause harm, therefore there is a need for tougher regulations of dietary supplements to ensure acceptable quality. Serdi and Springer Verlag France, 2013 Vitamin D nationallicence stability nationallicence analysis nationallicence marketed vitamin formulations nationallicence Garg Sanjay School of Pharmacy, University of Auckland, Auckland, New Zealand aut Sabri D. School of Pharmacy, University of Auckland, Auckland, New Zealand aut Kanji J. School of Pharmacy, University of Auckland, Auckland, New Zealand aut Rakkar P. School of Pharmacy, University of Auckland, Auckland, New Zealand aut Lee Y. School of Pharmacy, University of Auckland, Auckland, New Zealand aut Naidoo N. School of Pharmacy, University of Auckland, Auckland, New Zealand aut Svirskis D. School of Pharmacy, University of Auckland, Auckland, New Zealand aut The journal of nutrition, health & aging Springer-Verlag 17/2(2013-02-01), 158-161 1279-7707 17:2<158 2013 17 12603 https://doi.org/10.1007/s12603-012-0090-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0090-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garg Sanjay School of Pharmacy, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Sabri D. School of Pharmacy, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Kanji J. School of Pharmacy, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Rakkar P. School of Pharmacy, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Lee Y. School of Pharmacy, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Naidoo N. School of Pharmacy, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Svirskis D. School of Pharmacy, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/2(2013-02-01), 158-161 1279-7707 17:2<158 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer