naa a22 4500 510787428 CHVBK 20180411083307.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12041-013-0311-6 doi (NATIONALLICENCE)springer-10.1007/s12041-013-0311-6 QTL mapping for combining ability in different population-based NCII designs: a simulation study [Elektronische Daten] [LANZHI LI, CONGWEI SUN, YUAN CHEN, ZHIJUN DAI, ZHEN QU, XINGFEI ZHENG, SIBIN YU, TONGMIN MOU, CHENWU XU, ZHONGLI HU] The NCII design (North Carolina mating design II) has been widely applied in studies of combining ability and heterosis. The objective of our research was to estimate how different base populations, sample sizes, testcross numbers and heritability influence QTL analyses of combining ability and heterosis. A series of Monte Carlo simulation experiments with QTL mapping were then conducted for the base population performance, testcross population phenotypic values and the general combining ability (GCA), specific combining ability (SCA) and Hmp (midparental heterosis) datasets. The results indicated that: (i) increasing the number of testers did not necessarily enhance the QTL detection power for GCA, but it was significantly related to the QTL effect. (ii) The QTLs identified in the base population may be different from those from GCA dataset. Similar phenomena can be seen from QTL detected in SCA and Hmp datasets. (iii) The QTL detection power for GCA ranked in the order of DH(RIL) based > F2 based > BC based NCII design, when the heritability was low. The recombinant inbred lines (RILs) (or DHs) allows more recombination and offers higher mapping resolution than other populations. Further, their testcross progeny can be repeatedly generated and phenotyped. Thus, RIL based (or DH based) NCII design was highly recommend for combining ability QTL analysis. Our results expect to facilitate selecting elite parental lines with high combining ability and for geneticists to research the genetic basis of combining ability. Indian Academy of Sciences, 2013 combining ability nationallicence NCII design nationallicence QTL analysis nationallicence digenic nationallicence multiple alleles nationallicence LI LANZHI Hunan Provincial Key Laboratory for Biology and Control of Plant Disease and Insect Pests, College of Bio-Safety Science and Technology, Hunan Agricultural University, 410128, Changsha, People's Republic of China aut SUN CONGWEI Hunan Provincial Key Laboratory for Biology and Control of Plant Disease and Insect Pests, College of Bio-Safety Science and Technology, Hunan Agricultural University, 410128, Changsha, People's Republic of China aut CHEN YUAN Hunan Provincial Key Laboratory for Biology and Control of Plant Disease and Insect Pests, College of Bio-Safety Science and Technology, Hunan Agricultural University, 410128, Changsha, People's Republic of China aut DAI ZHIJUN Hunan Provincial Key Laboratory for Biology and Control of Plant Disease and Insect Pests, College of Bio-Safety Science and Technology, Hunan Agricultural University, 410128, Changsha, People's Republic of China aut QU ZHEN State Key Laboratory of Hybrid Rice, College of Life Science, Wuhan University, 430072, Wuhan, People's Republic of China aut ZHENG XINGFEI State Key Laboratory of Hybrid Rice, College of Life Science, Wuhan University, 430072, Wuhan, People's Republic of China aut YU SIBIN National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut MOU TONGMIN National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut XU CHENWU Division of Biostatistics and Quantitative Genetics, College of Agricultural Science, Yangzhou University, 225009, Yangzhou, People's Republic of China aut HU ZHONGLI State Key Laboratory of Hybrid Rice, College of Life Science, Wuhan University, 430072, Wuhan, People's Republic of China aut Journal of Genetics Springer India 92/3(2013-12-01), 529-543 0022-1333 92:3<529 2013 92 12041 https://doi.org/10.1007/s12041-013-0311-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12041-013-0311-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- LI LANZHI Hunan Provincial Key Laboratory for Biology and Control of Plant Disease and Insect Pests, College of Bio-Safety Science and Technology, Hunan Agricultural University, 410128, Changsha, People's Republic of China aut NATIONALLICENCE 700 1- SUN CONGWEI Hunan Provincial Key Laboratory for Biology and Control of Plant Disease and Insect Pests, College of Bio-Safety Science and Technology, Hunan Agricultural University, 410128, Changsha, People's Republic of China aut NATIONALLICENCE 700 1- CHEN YUAN Hunan Provincial Key Laboratory for Biology and Control of Plant Disease and Insect Pests, College of Bio-Safety Science and Technology, Hunan Agricultural University, 410128, Changsha, People's Republic of China aut NATIONALLICENCE 700 1- DAI ZHIJUN Hunan Provincial Key Laboratory for Biology and Control of Plant Disease and Insect Pests, College of Bio-Safety Science and Technology, Hunan Agricultural University, 410128, Changsha, People's Republic of China aut NATIONALLICENCE 700 1- QU ZHEN State Key Laboratory of Hybrid Rice, College of Life Science, Wuhan University, 430072, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- ZHENG XINGFEI State Key Laboratory of Hybrid Rice, College of Life Science, Wuhan University, 430072, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- YU SIBIN National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- MOU TONGMIN National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- XU CHENWU Division of Biostatistics and Quantitative Genetics, College of Agricultural Science, Yangzhou University, 225009, Yangzhou, People's Republic of China aut NATIONALLICENCE 700 1- HU ZHONGLI State Key Laboratory of Hybrid Rice, College of Life Science, Wuhan University, 430072, Wuhan, People's Republic of China aut NATIONALLICENCE 773 0- Journal of Genetics Springer India 92/3(2013-12-01), 529-543 0022-1333 92:3<529 2013 92 12041 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer