naa a22 4500 510787444 CHVBK 20180411083307.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12041-013-0272-9 doi (NATIONALLICENCE)springer-10.1007/s12041-013-0272-9 Tumour necrosis factor alpha ( TNF - α ) genetic polymorphisms and the risk of autoimmune liver disease: a meta-analysis [Elektronische Daten] [SHAN LI, XIAMEI HUANG, HUIZHI ZHONG, ZHIPING CHEN, QILIU PENG, YAN DENG, XUE QIN] Epidemiological studies have evaluated the association between tumour necrosis factor alpha (TNF-α)-308G/A and (TNF-α)-238G/A polymorphisms, and the risk of autoimmune liver disease (AILD), yet the results are conflicting. To derive a more precise estimation of the relationship, we performed this meta-analysis. A systematic review was conducted to identify all eligible studies of TNF-α polymorphisms and AILD risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association between the two TNF-α polymorphisms and AILD risk. A total of 15 eligible studies were identified. Overall, positive associations of -308G/A polymorphism with AILD risk were found (A vs G allele: OR= 1.45, 95%CI = 1.13-1.86; AA vs GG: OR= 2.74, 95%CI = 1.51-4.96; GA vs GG: OR = 1.46, 95%CI = 1.11-1.92; dominant model: OR = 1.57, 95%CI = 1.18-2.10; recessive model: OR = 2.22, 95%CI = 1.31-3.76). In subgroup analysis by ethnicity, a significantly higher risk was found in Caucasians. In subgroup analysis by AILD category, significant association was observed in autoimmune hepatitis and primary sclerosing cholangitis, especially in Caucasians. Patients carrying TNF-α-238A allele had a slightly decreased risk of developing AILD (OR = 0.65, 95%CI = 0.48-0.87). However, we found both TNF-α polymorphisms were not associated with primary biliary cirrhosis risk, even in subgroup analysis. Our meta-analysis suggests that the TNF-α-308G/A and -238G/A polymorphisms may contribute to AILD susceptibility in Caucasians, especially for autoimmune hepatitis and primary sclerosing cholangitis. Nevertheless, we found both TNF-α polymorphisms were unlikely to be associated with the risk of primary biliary cirrhosis. Indian Academy of Sciences, 2013 polymorphism nationallicence tumour necrosis factor alpha nationallicence autoimmune liver disease nationallicence meta-analysis nationallicence LI SHAN Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut HUANG XIAMEI Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut ZHONG HUIZHI Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut CHEN ZHIPING Department of Occupational Health and Environmental Health, School of Public Health at Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut PENG QILIU Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut DENG YAN Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut QIN XUE Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut Journal of Genetics Springer India 92/3(2013-12-01), 617-628 0022-1333 92:3<617 2013 92 12041 https://doi.org/10.1007/s12041-013-0272-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12041-013-0272-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- LI SHAN Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut NATIONALLICENCE 700 1- HUANG XIAMEI Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut NATIONALLICENCE 700 1- ZHONG HUIZHI Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut NATIONALLICENCE 700 1- CHEN ZHIPING Department of Occupational Health and Environmental Health, School of Public Health at Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut NATIONALLICENCE 700 1- PENG QILIU Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut NATIONALLICENCE 700 1- DENG YAN Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut NATIONALLICENCE 700 1- QIN XUE Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut NATIONALLICENCE 773 0- Journal of Genetics Springer India 92/3(2013-12-01), 617-628 0022-1333 92:3<617 2013 92 12041 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer