naa a22 4500 510787622 CHVBK 20180411083308.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12041-013-0281-8 doi (NATIONALLICENCE)springer-10.1007/s12041-013-0281-8 Analysis of dinucleotide signatures in HIV-1 subtype B genomes [Elektronische Daten] [ARIDAMAN PANDIT, JYOTHIRMAYI VADLAMUDI, SOMDATTA SINHA] Dinucleotide usage is known to vary in the genomes of organisms. The dinucleotide usage profiles or genome signatures are similar for sequence samples taken from the same genome, but are different for taxonomically distant species. This concept of genome signatures has been used to study several organisms including viruses, to elucidate the signatures of evolutionary processes at the genome level. Genome signatures assume greater importance in the case of host-pathogen interactions, where molecular interactions between the two species take place continuously, and can influence their genomic composition. In this study, analyses of whole genome sequences of the HIV-1 subtype B, a retrovirus that caused global pandemic of AIDS, have been carried out to analyse the variation in genome signatures of the virus from 1983 to 2007. We show statistically significant temporal variations in some dinucleotide patterns highlighting the selective evolution of the dinucleotide profiles of HIV-1 subtype B, possibly a consequence of host specific selection. Indian Academy of Sciences, 2013 genome signature nationallicence DRAP nationallicence HIV-1 nationallicence chaos game representation nationallicence PANDIT ARIDAMAN Centre for Cellular and Molecular Biology (CSIR), 500 007, Hyderabad, India aut VADLAMUDI JYOTHIRMAYI Centre for Cellular and Molecular Biology (CSIR), 500 007, Hyderabad, India aut SINHA SOMDATTA Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector 81, SAS Nagar, 140 306, Manauli, India aut Journal of Genetics Springer India 92/3(2013-12-01), 403-412 0022-1333 92:3<403 2013 92 12041 https://doi.org/10.1007/s12041-013-0281-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12041-013-0281-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- PANDIT ARIDAMAN Centre for Cellular and Molecular Biology (CSIR), 500 007, Hyderabad, India aut NATIONALLICENCE 700 1- VADLAMUDI JYOTHIRMAYI Centre for Cellular and Molecular Biology (CSIR), 500 007, Hyderabad, India aut NATIONALLICENCE 700 1- SINHA SOMDATTA Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector 81, SAS Nagar, 140 306, Manauli, India aut NATIONALLICENCE 773 0- Journal of Genetics Springer India 92/3(2013-12-01), 403-412 0022-1333 92:3<403 2013 92 12041 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer