naa a22 4500 510788157 CHVBK 20180411083310.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12041-013-0262-y doi (NATIONALLICENCE)springer-10.1007/s12041-013-0262-y Search for missing schizophrenia genes will require a new developmental neurogenomic perspective [Elektronische Daten] [H. KUMAR, CHRISTINA CASTELLANI, SUJIT MAITI, RICHARD O'REILLY, SHIVA SINGH] Even the most powerful experimental designs in search of genetic causes of schizophrenia have not met the desired goal. It is imperative to review the reasons for such an outcome and to formulate novel strategies for the future direction of this research in the new era of individual genomes. Here, we will review aspects of neurodevelopmental hypothesis of schizophrenia in the light of novel genomic and epigenomic insights. Specifically, we will argue for the involvement of de novo mutations and epigenetic modifications during neurodevelopment that may result in schizophrenia. Our conclusion is that the successful elucidation of hereditary mechanisms in neuropsychiatric disorders must begin with attention to discrete endophenotypes; consideration of ontogeny, forethought of genome structure including temporal and spatial patterns of (epi) mutations and the use of judicious techniques that go beyond association studies. Indian Academy of Sciences, 2013 schizophrenia nationallicence neurodevelopment nationallicence differentiation nationallicence de novo mutations and epimutations (DNM/DNeM) nationallicence KUMAR H. Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut CASTELLANI CHRISTINA Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut MAITI SUJIT Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut O'REILLY RICHARD Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut SINGH SHIVA Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut Journal of Genetics Springer India 92/2(2013-08-01), 335-340 0022-1333 92:2<335 2013 92 12041 https://doi.org/10.1007/s12041-013-0262-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12041-013-0262-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KUMAR H. Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut NATIONALLICENCE 700 1- CASTELLANI CHRISTINA Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut NATIONALLICENCE 700 1- MAITI SUJIT Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut NATIONALLICENCE 700 1- O'REILLY RICHARD Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut NATIONALLICENCE 700 1- SINGH SHIVA Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, N6A 5B7, London, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Genetics Springer India 92/2(2013-08-01), 335-340 0022-1333 92:2<335 2013 92 12041 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer