naa a22 4500 510799272 CHVBK 20180411083347.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12028-013-9821-6 doi (NATIONALLICENCE)springer-10.1007/s12028-013-9821-6 Is There Any Association Between Cerebral Vasoconstriction/Vasodilatation and Microdialysis Lactate to Pyruvate Ratio Increase? [Elektronische Daten] [Shadnaz Asgari, Paul Vespa, Xiao Hu] Background: Although abnormally high Lactate/Pyruvate ratio (LPR) could indicate cerebral ischemia for brain injury patients, there is a debate on what is primary factor responsible for LPR increase. Methods: A data analysis experiment is taken to test whether any association between cerebral vasodilatation/vasoconstriction and LPR increase exists. We studied 4,316 microdialysis data samples collected in an average interval of 1.3h from 30 severe traumatic brain injury (TBI) patients. The LPR increase episodes were automatically identified using a moving time-window of 5 samples. A novel pulse morphological template matching (PMTM) algorithm was applied to the intracranial pressure (ICP) data of the corresponding patients to assess the occurrence of cerebral vasodilatation and vasoconstriction during the identified LPR increase episodes. Several analyses were performed to evaluate the association between cerebral vasoconstriction/vasodilatation and LPR increase. Results: Results revealed that although more than half of the LPR increase episodes are not associated with any detected cerebral vasoconstriction/vasodilatation, when a vaso-change happens in association of LPR increase, it is more likely that this vaso-change is in the form of vasoconstriction rather than vasodilatation. Also for few subjects with dominant number of vasoconstriction episodes, a causality relationship between vasoconstriction and LPR increase were observed (vasoconstriction precedes LPR increase). Conclusions: Using continuous intracranial pressure monitoring and our pulse morphological template matching (PMTM) algorithm could be potentially helpful in teasing out whether culprit cerebral vascular changes precede metabolic crisis for traumatic brain injury patients and hence guiding the management of this condition. Springer Science+Business Media New York, 2013 Hemodynamic signal nationallicence Microdialysis nationallicence Lactate/Pyruvate ratio nationallicence Cerebral vasodilatation nationallicence Cerebral vasoconstriction nationallicence Metabolic crisis nationallicence Asgari Shadnaz Department of Computer Engineering and Computer Science, California State University, Long Beach, CA, USA aut Vespa Paul Neural Systems and Dynamics Laboratory, Department of Neurosurgery David Geffen School of Medicine, University of California, 18-265 Semel, 10833 Le Conte Avenue, Box 703919, 90095, Los Angeles, CA, USA aut Hu Xiao Neural Systems and Dynamics Laboratory, Department of Neurosurgery David Geffen School of Medicine, University of California, 18-265 Semel, 10833 Le Conte Avenue, Box 703919, 90095, Los Angeles, CA, USA aut Neurocritical Care Springer US; http://www.springer-ny.com 19/1(2013-08-01), 56-64 1541-6933 19:1<56 2013 19 12028 https://doi.org/10.1007/s12028-013-9821-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-013-9821-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Asgari Shadnaz Department of Computer Engineering and Computer Science, California State University, Long Beach, CA, USA aut NATIONALLICENCE 700 1- Vespa Paul Neural Systems and Dynamics Laboratory, Department of Neurosurgery David Geffen School of Medicine, University of California, 18-265 Semel, 10833 Le Conte Avenue, Box 703919, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Hu Xiao Neural Systems and Dynamics Laboratory, Department of Neurosurgery David Geffen School of Medicine, University of California, 18-265 Semel, 10833 Le Conte Avenue, Box 703919, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Neurocritical Care Springer US; http://www.springer-ny.com 19/1(2013-08-01), 56-64 1541-6933 19:1<56 2013 19 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer