naa a22 4500 510799426 CHVBK 20180411083348.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12028-012-9706-0 doi (NATIONALLICENCE)springer-10.1007/s12028-012-9706-0 Regional Brain Injury on Conventional and Diffusion Weighted MRI is Associated with Outcome After Pediatric Cardiac Arrest [Elektronische Daten] [Ericka Fink, A. Panigrahy, R. Clark, C. Fitz, D. Landsittel, P. Kochanek, G. Zuccoli] Background: To assess regional brain injury on magnetic resonance imaging (MRI) after pediatric cardiac arrest (CA) and to associate regional injury with patient outcome and effects of hypothermia therapy for neuroprotection. Methods: We performed a retrospective chart review with prospective imaging analysis. Children between 1week and 17years of age who had a brain MRI in the first 2weeks after CA without other acute brain injury between 2002 and 2008 were included. Brain MRI (1.5 T General Electric, Milwaukee, WI, USA) images were analyzed by 2 blinded neuroradiologists with adjudication; images were visually graded. Brain lobes, basal ganglia, thalamus, brain stem, and cerebellum were analyzed using T1, T2, and diffusion-weighted images (DWI). Results: We examined 28 subjects with median age 1.9years (IQR 0.4-13.0) and 19 (68%) males. Increased intensity on T2 in the basal ganglia and restricted diffusion in the brain lobes were associated with unfavorable outcome (all P<0.05). Therapeutic hypothermia had no effect on regional brain injury. Repeat brain MRI was infrequently performed but demonstrated evolution of lesions. Conclusion: Children with lesions in the basal ganglia on conventional MRI and brain lobes on DWI within the first 2weeks after CA represent a group with increased risk of poor outcome. These findings may be important for developing neuroprotective strategies based on regional brain injury and for evaluating response to therapy in interventional clinical trials. Springer Science+Business Media, LLC, 2012 Cardiac arrest nationallicence Neurological outcome nationallicence MRI nationallicence Pediatric nationallicence Brain injury nationallicence Fink Ericka Department of Critical Care Medicine, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Faculty Pavilion, 2nd floor, 15224, Pittsburgh, PA, USA aut Panigrahy A. Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA aut Clark R. Department of Critical Care Medicine, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Faculty Pavilion, 2nd floor, 15224, Pittsburgh, PA, USA aut Fitz C. Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA aut Landsittel D. Department of Internal Medicine, Center for Research on Health Care Data Center, UPMC, Pittsburgh, PA, USA aut Kochanek P. Department of Critical Care Medicine, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Faculty Pavilion, 2nd floor, 15224, Pittsburgh, PA, USA aut Zuccoli G. Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA aut Neurocritical Care Springer US; http://www.springer-ny.com 19/1(2013-08-01), 31-40 1541-6933 19:1<31 2013 19 12028 https://doi.org/10.1007/s12028-012-9706-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9706-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fink Ericka Department of Critical Care Medicine, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Faculty Pavilion, 2nd floor, 15224, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Panigrahy A. Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Clark R. Department of Critical Care Medicine, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Faculty Pavilion, 2nd floor, 15224, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Fitz C. Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Landsittel D. Department of Internal Medicine, Center for Research on Health Care Data Center, UPMC, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Kochanek P. Department of Critical Care Medicine, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Faculty Pavilion, 2nd floor, 15224, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Zuccoli G. Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Neurocritical Care Springer US; http://www.springer-ny.com 19/1(2013-08-01), 31-40 1541-6933 19:1<31 2013 19 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer