naa a22 4500 510799434 CHVBK 20180411083348.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12028-012-9686-0 doi (NATIONALLICENCE)springer-10.1007/s12028-012-9686-0 The Oxygen Reactivity Index and Its Relation to Sensor Technology in Patients with Severe Brain Lesions [Elektronische Daten] [Julius Dengler, Christin Frenzel, Peter Vajkoczy, Peter Horn, Stefan Wolf] Background: The oxygen reactivity index (ORx) has been introduced to assess the status of cerebral autoregulation after traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH). Currently, there is some controversy about whether the ORx depends on the type of PbrO2-sensor technology used for its calculation. To examine if the probe technology does matter, we compared the ORx and the resulting optimal cerebral perfusion pressures (CPPopt) of simultaneously implanted Licox (CC1.SB, Integra Neuroscience, France) and Neurovent-PTO (Raumedic, Germany) probes in patients after aneurysmal SAH or severe TBI. Methods: Licox and Raumedic probes were implanted side by side in 11 patients after TBI or SAH. ORx and CPPopt were recorded continuously. The equivalence of both probes was examined using Bland-Altman analyses. Results: The mean difference in ORx was 0.1, with Licox producing higher values. The limits of agreement regarding ORx ranged from −0.6 to +0.7. When both probes' ORx values were compared in each patient, no specific pattern in their relationship was seen. The mean difference in CPPopt was 0mmHg with limits of agreement between −16.5 and +16.4mmHg. Conclusions: Owing to the rather limited number of patients, we view the results of this study as preliminary. The main result is that Licox and Raumedic showed consistent differences in ORx and CPPopt. Therefore, ORx values of both probes cannot be interchanged and should not be viewed as equivalent. This should be taken into consideration when discussing ORx data generated by different PbrO2 probe types. Springer Science+Business Media, LLC, 2012 ORx nationallicence Licox nationallicence Raumedic nationallicence Cerebral tissue oxygenation nationallicence PbrO2 nationallicence Cerebral autoregulation nationallicence Dengler Julius Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut Frenzel Christin Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut Vajkoczy Peter Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut Horn Peter Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut Wolf Stefan Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut Neurocritical Care Springer US; http://www.springer-ny.com 19/1(2013-08-01), 74-78 1541-6933 19:1<74 2013 19 12028 https://doi.org/10.1007/s12028-012-9686-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9686-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dengler Julius Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut NATIONALLICENCE 700 1- Frenzel Christin Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut NATIONALLICENCE 700 1- Vajkoczy Peter Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut NATIONALLICENCE 700 1- Horn Peter Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut NATIONALLICENCE 700 1- Wolf Stefan Department of Neurosurgery, Charité, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany aut NATIONALLICENCE 773 0- Neurocritical Care Springer US; http://www.springer-ny.com 19/1(2013-08-01), 74-78 1541-6933 19:1<74 2013 19 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer