naa a22 4500 510799477 CHVBK 20180411083348.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12028-013-9926-y doi (NATIONALLICENCE)springer-10.1007/s12028-013-9926-y Validation of Clinical Prediction Scores in Patients with Primary Intracerebral Hemorrhage [Elektronische Daten] [John Garrett, Mehrzad Zarghouni, Kennith Layton, Dion Graybeal, Yahya Daoud] Background: Initial reports of the FUNC score suggest that it may accurately identify those patients suffering from intracerebral hemorrhage (ICH) with an ultra low chance of functional neurologic recovery. This study's aim is to validate the FUNC score and determine if it accurately identifies the cohort of patients with an ultra low chance of survival with good neurologic recovery. Methods: Retrospective review of 501 consecutive primary ICH patients admitted from the Emergency Department to a large healthcare system. Performance of the FUNC, ICH-GS, and oICH scores was determined by calculating areas under the receiver-operator-characteristic curves. Patients with a predicted 100% chance of poor neurologic outcome (PNO) (FUNC <4 and ICH-GS >10) scores were evaluated to determine if DNR impacted 90day survival or rate of survival with a Glasgow Outcome Score of <3. Results: In 366 cases of primary ICH who presented during the study period, 222(61%) survived to discharge. Both the FUNC (AUC: 0.873) and ICH-GS (AUC: 0.888) outperformed the oICH (AUC: 0.743) in predicting 90-day mortality (p=<0.001). Of 68 patients with a FUNC score <4, 67 (98.5%) had PNO at discharge. The presence of DNR was not associated with a significant difference in the rate of PNO at discharge (40/40=100% vs. 27/28=96.4% p=0.42) or 90-day mortality (40/40=100% vs. 21/28=75%, p=0.06). Conclusion: The FUNC and ICH-GS appear superior to the oICH in predicting outcome in patients with primary ICH. In addition, the FUNC score appears to accurately identify patients with low chance of functional neurologic recovery at discharge. Springer Science+Business Media New York, 2013 Intracerebral hemorrhage nationallicence Stroke nationallicence Risk stratification nationallicence Prognosis nationallicence End of life nationallicence FUNC nationallicence Garrett John Department of Emergency Medicine, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA aut Zarghouni Mehrzad Department of Radiology, Baylor University Medical Center, Dallas, TX, USA aut Layton Kennith Division of Neuro-Interventional Radiology, Department of Radiology, Baylor University Medical Center, Dallas, TX, USA aut Graybeal Dion Department of Neuroscience, Baylor University Medical Center, Dallas, TX, USA aut Daoud Yahya Department of Quantitative Sciences, Institute for Health Care Research and Improvement, Baylor Healthcare System, Dallas, TX, USA aut Neurocritical Care Springer US; http://www.springer-ny.com 19/3(2013-12-01), 329-335 1541-6933 19:3<329 2013 19 12028 https://doi.org/10.1007/s12028-013-9926-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-013-9926-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garrett John Department of Emergency Medicine, Baylor University Medical Center, 3500 Gaston Avenue, 75246, Dallas, TX, USA aut NATIONALLICENCE 700 1- Zarghouni Mehrzad Department of Radiology, Baylor University Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Layton Kennith Division of Neuro-Interventional Radiology, Department of Radiology, Baylor University Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Graybeal Dion Department of Neuroscience, Baylor University Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Daoud Yahya Department of Quantitative Sciences, Institute for Health Care Research and Improvement, Baylor Healthcare System, Dallas, TX, USA aut NATIONALLICENCE 773 0- Neurocritical Care Springer US; http://www.springer-ny.com 19/3(2013-12-01), 329-335 1541-6933 19:3<329 2013 19 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer