naa a22 4500 510799736 CHVBK 20180411083349.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12028-013-9873-7 doi (NATIONALLICENCE)springer-10.1007/s12028-013-9873-7 QTc-Prolongation in Posterior Circulation Stroke [Elektronische Daten] [Nils Henninger, Diogo Haussen, Nikolaos Kakouros, Magdy Selim, D. Searls, Sandeep Kumar, Gottfried Schlaug, Louis Caplan] Background and Purpose: To evaluate the relationship between infarct location and QTc-prolongation in patients with posterior circulation strokes. Methods: Admission electrocardiograms (ECG) of 131 patients among a prospective sample of 407 consecutive adult patients in the New England Medical Center Posterior Circulation Registry were retrospectively analyzed. The QT interval (ms) was measured and corrected using Bazett's formula (QTcBazett) as well as linear regression functions (QTcLinear). QTcBazett>440ms and QTcLinear≥450ms for men (≥460ms for women) were considered prolonged. Multivariable linear and logistic regression analyses were used to identify independent predictors of the QTc. Results: Overall, 34% of patients had a prolonged QTcBazett and 7% had a prolonged QTcLinear noted on the admission ECG. There was a significant association between temporal lobe infarction and QTcBazett and QTcLinear (p<0.001 for both) in multivariable linear regression analyses adjusting for demographics, ECG parameters, and preadmission medication use. In multivariable logistic regression analysis, temporal lobe infarction emerged as an independent predictor of prolonged QTcBazett (p=0.009) and QTcLinear (p=0.008), respectively. Sensitivity analyses excluding patients with transient ischemic attack yielded similar results. Exploratory analyses indicated that patients with temporal lobe infarction had worse functional 30-day outcomes in multivariable logistic regression (p=0.022). However, there was no significant association between QTc and 30-day functional outcome. Conclusions: QTc-prolongation is common after posterior circulation stroke and associated with temporal lobe infarction. Prospective studies are needed to confirm these preliminary findings and to examine potential long-term consequences. Springer Science+Business Media New York, 2013 Basilar artery nationallicence Brainstem nationallicence Electrocardiogram nationallicence Posterior cerebral artery nationallicence QTc nationallicence Temporal lobe nationallicence Henninger Nils Department of Neurology, UMass Medical School, 55 Lake Ave, North, 01655, Worcester, MA, USA aut Haussen Diogo Department of Endovascular Surgical Neuroradiology, Jackson Memorial Hospital, Miami, FL, USA aut Kakouros Nikolaos Department of Cardiology, UMass Medical School, Worcester, MA, USA aut Selim Magdy Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut Searls D. Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut Kumar Sandeep Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut Schlaug Gottfried Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut Caplan Louis Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut Neurocritical Care Springer US; http://www.springer-ny.com 19/2(2013-10-01), 167-175 1541-6933 19:2<167 2013 19 12028 https://doi.org/10.1007/s12028-013-9873-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-013-9873-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Henninger Nils Department of Neurology, UMass Medical School, 55 Lake Ave, North, 01655, Worcester, MA, USA aut NATIONALLICENCE 700 1- Haussen Diogo Department of Endovascular Surgical Neuroradiology, Jackson Memorial Hospital, Miami, FL, USA aut NATIONALLICENCE 700 1- Kakouros Nikolaos Department of Cardiology, UMass Medical School, Worcester, MA, USA aut NATIONALLICENCE 700 1- Selim Magdy Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Searls D. Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Kumar Sandeep Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Schlaug Gottfried Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Caplan Louis Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA aut NATIONALLICENCE 773 0- Neurocritical Care Springer US; http://www.springer-ny.com 19/2(2013-10-01), 167-175 1541-6933 19:2<167 2013 19 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer