naa a22 4500 510799744 CHVBK 20180411083349.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12028-013-9837-y doi (NATIONALLICENCE)springer-10.1007/s12028-013-9837-y Augmented Renal Clearance of Vancomycin and Levetiracetam in a Traumatic Brain Injury Patient [Elektronische Daten] [Aaron Cook, Shaily Arora, Justin Davis, Thomas Pittman] Background: Increased creatinine clearance and subsequent elevated antimicrobial clearance is evident in many traumatic brain injury (TBI) patients due to augmented renal clearance (ARC). Little is known about the effects of ARC on other renally-eliminated medications, such as the anti-epileptic drug levetiracetam. Methods: This is a case report of serum monitoring of vancomycin and levetiracetam in a 22 year old female with ARC after severe TBI. Results: The patient exhibited ARC of vancomycin as evidenced by her low serum concentrations with standard vancomycin dosing. Her estimated creatinine clearance based on vancomycin clearance was 243.9ml/min. Serum concentrations also suggested ARC of levetiracetam. No toxicities for either medication were noted, even after dose adjustment to account for possible ARC. Conclusions: Vancomycin and levetiracetam both appear to be subject to ARC after TBI. Clinicians should be mindful that standard dosing of these agents may not achieve typical target concentrations in this clinical scenario. Springer Science+Business Media New York, 2013 Closed head injury nationallicence Pharmacokinetics nationallicence Antibiotic nationallicence Antiepileptic nationallicence Creatinine clearance nationallicence Cook Aaron University of Kentucky Pharmacy Services, Lexington, KY, USA aut Arora Shaily University of Kentucky Pharmacy Services, Lexington, KY, USA aut Davis Justin Department of Neurosurgery, University of Kentucky, Lexington, KY, USA aut Pittman Thomas Department of Neurosurgery, University of Kentucky, Lexington, KY, USA aut Neurocritical Care Springer US; http://www.springer-ny.com 19/2(2013-10-01), 210-214 1541-6933 19:2<210 2013 19 12028 https://doi.org/10.1007/s12028-013-9837-y text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-013-9837-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cook Aaron University of Kentucky Pharmacy Services, Lexington, KY, USA aut NATIONALLICENCE 700 1- Arora Shaily University of Kentucky Pharmacy Services, Lexington, KY, USA aut NATIONALLICENCE 700 1- Davis Justin Department of Neurosurgery, University of Kentucky, Lexington, KY, USA aut NATIONALLICENCE 700 1- Pittman Thomas Department of Neurosurgery, University of Kentucky, Lexington, KY, USA aut NATIONALLICENCE 773 0- Neurocritical Care Springer US; http://www.springer-ny.com 19/2(2013-10-01), 210-214 1541-6933 19:2<210 2013 19 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer