naa a22 4500 510799868 CHVBK 20180411083350.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12028-012-9788-8 doi (NATIONALLICENCE)springer-10.1007/s12028-012-9788-8 Anti-N-Methyl-D-Aspartate Receptor Encephalitis with Favorable Outcome Despite Prolonged Status Epilepticus [Elektronische Daten] [Xavier Finné Lenoir, Christian Sindic, Vincent van Pesch, Souraya El Sankari, Marianne de Tourtchaninoff, Roger Denays, Philippe Hantson] Background: To describe a case of auto-immune encephalitis in an adolescent with favorable outcome despite prolonged status epilepticus. Methods: A 17year old Asian man without previous medical history developed alteration of consciousness and partial seizures. The diagnosis of anti-N-methyl-D-aspartate receptor encephalitis was confirmed by the detection of specific antibodies in both cerebrospinal fluid and serum. Results: The clinical course was complicated by prolonged status epilepticus which was refractory to a large number of antiepileptic drugs, including barbiturate coma. Immunomodulatory therapy included steroids, plasma exchanges, and intravenous immunoglobulins. After 86days of intensive therapy, the patient regained consciousness progressively. Brain magnetic resonance imaging never demonstrated any lesion. Extensive search for a tumor was negative. At 12month follow-up, the patient had made an excellent recovery. Conclusion: Auto-immune encephalitis is likely underdiagnosed in adolescents. In their most severe presentation, seizures may be resistant to a large number of anti-epileptic drugs, and the clinical improvement seems to be mainly because of the immunomodulatory therapy. Relapse is possible, as well as the delayed development of a teratoma or other tumor. Springer Science+Business Media New York, 2012 Encephalitis nationallicence Anti-NMDA receptor antibodies nationallicence Status epilepticus nationallicence Seizure management nationallicence Ketamine nationallicence Immunosuppressive therapy nationallicence Finné Lenoir Xavier Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Avenue Hippocrate, 10, 1200, Brussels, Belgium aut Sindic Christian Department of Neurology, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium aut van Pesch Vincent Department of Neurology, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium aut El Sankari Souraya Department of Neurology, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium aut de Tourtchaninoff Marianne Department of Neurology, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium aut Denays Roger Department of Neurology, Centre Hospitalier Régional de Namur, Namur, Belgium aut Hantson Philippe Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Avenue Hippocrate, 10, 1200, Brussels, Belgium aut Neurocritical Care Humana Press Inc 18/1(2013-02-01), 89-92 1541-6933 18:1<89 2013 18 12028 https://doi.org/10.1007/s12028-012-9788-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9788-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Finné Lenoir Xavier Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Avenue Hippocrate, 10, 1200, Brussels, Belgium aut NATIONALLICENCE 700 1- Sindic Christian Department of Neurology, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium aut NATIONALLICENCE 700 1- van Pesch Vincent Department of Neurology, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium aut NATIONALLICENCE 700 1- El Sankari Souraya Department of Neurology, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium aut NATIONALLICENCE 700 1- de Tourtchaninoff Marianne Department of Neurology, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium aut NATIONALLICENCE 700 1- Denays Roger Department of Neurology, Centre Hospitalier Régional de Namur, Namur, Belgium aut NATIONALLICENCE 700 1- Hantson Philippe Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Avenue Hippocrate, 10, 1200, Brussels, Belgium aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/1(2013-02-01), 89-92 1541-6933 18:1<89 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer