naa a22 4500 510799876 CHVBK 20180411083350.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12028-011-9622-8 doi (NATIONALLICENCE)springer-10.1007/s12028-011-9622-8 Neuroendocrine Changes in Patients with Spontaneous Supratentorial Intracerebral Hemorrhage [Elektronische Daten] [Hagen Huttner, Ines-Christine Kiphuth, Linda Teuber, Hannes Lücking, Stephan Kloska, Dimitre Staykov, Joji Kuramatsu, Christoph Mauer, Lorenz Breuer, Arnd Doerfler, Martin Köhrmann] Background: Neuroendocrine changes have been reported after ischemic stroke, subarachnoid hemorrhage, and brain trauma. As there are no corresponding data in patients with intracerebral hemorrhage (ICH) we analyzed various neuroendocrine parameters to investigate possible alterations in hormone profiles of patients with ICH. Methods: Twenty patients with ICH were prospectively enrolled in the study. Patients were a priori parted into two groups: Ten non-ventilated patients treated on the stroke-unit (hemorrhage volumes <20ml, "small ICH”), and 10 ventilated patients treated on the neurocritical care unit (hematoma volumes >20ml with possible additional ventricular involvement ("large ICH”). Neuroendocrine parameters were compared between both groups referring to reference values. The following parameters were obtained over a period of 9 days in 20 patients with spontaneous supratentorial ICH: thyrotropin, free thiiodothyronine and thyroxine, human growth hormone, insulin-like growth factor 1, luteinizing hormone, follicle-stimulating hormone, testosterone, prolactin, adrenocorticotropic hormone, and cortisol. Results: Small ICH patients were in a median 71 (54-88) years old and had a mean ICH volume of 9.5±6.5ml, whereas large ICH patients were 65 (47-80) years old and showed a mean volume of 56±30.2ml. None of the patients revealed pathological alterations for thyrotropin, free thiiodothyronine, thyroxine, human growth hormone, insulin-like growth factor 1, and testosterone. There was only a mild decrease of adrenocorticotropic hormone and cortisol on day 3 in large ICH patients. Small ICH patients showed pathologically elevated levels of luteinizing and follicle-stimulating hormone throughout the observation period. Large ICH patients showed a marked increase of prolactin that developed during the course. Conclusions: Overall, neuroendocrine changes in ICH patients are not as profound as reported for ischemic stroke or subarachnoid hemorrhage. The clinical significance of increased LH and FSH levels in small ICH is unclear, whereas elevation of prolactin in large ICH was anticipated. Future randomized controlled trials should also focus on neuroendocrine parameters to clarify the impact of possible hormonal alterations on functional outcome. Springer Science+Business Media, LLC, 2011 Neuroendocrine nationallicence Intracerebral hemorrhage nationallicence Hormone profile nationallicence Huttner Hagen Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Kiphuth Ines-Christine Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Teuber Linda Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Lücking Hannes Department of Neuroradiology, University of Erlangen, Erlangen, Germany aut Kloska Stephan Department of Neuroradiology, University of Erlangen, Erlangen, Germany aut Staykov Dimitre Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Kuramatsu Joji Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Mauer Christoph Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Breuer Lorenz Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Doerfler Arnd Department of Neuroradiology, University of Erlangen, Erlangen, Germany aut Köhrmann Martin Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut Neurocritical Care Humana Press Inc 18/1(2013-02-01), 39-44 1541-6933 18:1<39 2013 18 12028 https://doi.org/10.1007/s12028-011-9622-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-011-9622-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huttner Hagen Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Kiphuth Ines-Christine Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Teuber Linda Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Lücking Hannes Department of Neuroradiology, University of Erlangen, Erlangen, Germany aut NATIONALLICENCE 700 1- Kloska Stephan Department of Neuroradiology, University of Erlangen, Erlangen, Germany aut NATIONALLICENCE 700 1- Staykov Dimitre Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Kuramatsu Joji Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Mauer Christoph Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Breuer Lorenz Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Doerfler Arnd Department of Neuroradiology, University of Erlangen, Erlangen, Germany aut NATIONALLICENCE 700 1- Köhrmann Martin Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/1(2013-02-01), 39-44 1541-6933 18:1<39 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer