naa a22 4500 510799884 CHVBK 20180411083350.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12028-012-9782-1 doi (NATIONALLICENCE)springer-10.1007/s12028-012-9782-1 Effectiveness and Safety of Nicardipine and Labetalol Infusion for Blood Pressure Management in Patients with Intracerebral and Subarachnoid Hemorrhage [Elektronische Daten] [Santiago Ortega-Gutierrez, Jiz Thomas, Andres Reccius, Sachin Agarwal, Hector Lantigua, Min Li, Amanda Carpenter, Stephan Mayer, J. Schmidt, Kiwon Lee, Jan Claassen, Neeraj Badjatia, Christine Lesch] Background: Nicardipine and labetalol are two commonly used antihypertensives for treating elevated blood pressures in the setting of intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). There are no studies comparing these two agents as continuous infusions. Methods: A retrospective chart review was conducted of patients admitted between November 2009 and January 2011 with ICH and SAH to compare effectiveness and safety between both agents. Percent time spent at goal was set as the primary outcome. The secondary outcomes included blood pressure variability, time to goal, incidence of bradycardia, tachycardia, and hypotension. Results: A total of 81 patients were available for analysis, 10 initiated on labetalol (LAB), 57 on nicardipine (NIC), and 14 required the combination of these agents (COMB) to reach goal. We found no difference between NIC, LAB, and the COMB groups in the median percent time at goal [88% (61-98); 93% (51-99); 66% (25-95), (p=NS)]. Median percentage of blood pressure variability, hypotension, and bradycardia were also comparable between groups, however, more tachycardia was observed in the COMB group versus both LAB and NIC groups (45 vs. 0 vs. 3%; p<0.001). Mean time to goal SBP in 24 patients who had BP readings available at 1sth of initiation was 32±34min in the NIC group and 53±42min in the LAB group (p=0.03). Conclusions: Both agents appear equally effective and safe for blood pressure control in SAH and ICH during the initial admission hours. A prospective study is needed to validate these findings. Springer Science+Business Media New York, 2012 Labetalol nationallicence Nicardipine nationallicence Blood pressure nationallicence ICH nationallicence SAH nationallicence Ortega-Gutierrez Santiago Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Thomas Jiz Department of Pharmacy, NewYork-Presbyterian Hospital, 622 W. 168th Street, VC Basement, 10032, New York, NY, USA aut Reccius Andres Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Agarwal Sachin Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Lantigua Hector Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Li Min Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Carpenter Amanda Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Mayer Stephan Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Schmidt J. Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Lee Kiwon Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Claassen Jan Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Badjatia Neeraj Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Lesch Christine Department of Pharmacy, NewYork-Presbyterian Hospital, 622 W. 168th Street, VC Basement, 10032, New York, NY, USA aut Neurocritical Care Humana Press Inc 18/1(2013-02-01), 13-19 1541-6933 18:1<13 2013 18 12028 https://doi.org/10.1007/s12028-012-9782-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9782-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ortega-Gutierrez Santiago Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Thomas Jiz Department of Pharmacy, NewYork-Presbyterian Hospital, 622 W. 168th Street, VC Basement, 10032, New York, NY, USA aut NATIONALLICENCE 700 1- Reccius Andres Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Agarwal Sachin Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Lantigua Hector Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Li Min Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Carpenter Amanda Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Mayer Stephan Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Schmidt J. Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Lee Kiwon Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Claassen Jan Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Badjatia Neeraj Division of Neurocritical Care, The Neurologic Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Lesch Christine Department of Pharmacy, NewYork-Presbyterian Hospital, 622 W. 168th Street, VC Basement, 10032, New York, NY, USA aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/1(2013-02-01), 13-19 1541-6933 18:1<13 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer