naa a22 4500 510799973 CHVBK 20180411083350.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12028-012-9780-3 doi (NATIONALLICENCE)springer-10.1007/s12028-012-9780-3 Intracranial Pressure Dose and Outcome in Traumatic Brain Injury [Elektronische Daten] [Kevin Sheth, Deborah Stein, Bizhan Aarabi, Peter Hu, Joseph Kufera, Thomas Scalea, Daniel Hanley] Objective: Detecting and treating elevated intracranial pressure (ICP) is a cornerstone of management in patients with severe traumatic brain injury. The aim of this study was to determine the association between area under the curve measurement of elevated ICP and clinical outcome. Methods: Single center observational study using prospectively collected data at a University hospital, level one-trauma center. Sixty prospective patients with severe traumatic brain injury were prospectively enrolled over a 2-year period. Intracranial pressure measurements were captured using a real-time automated, high resolution vital signs data recording system. Mortality and functional outcome were assessed at 30days, 3 and 6months using Extended Glasgow Outcome Scale. Results: Increasing elevated intracranial pressure time dose was associated with mortality (OR 1.08; 95% confidence interval [CI], 1.01-1.15, p=0.03) and poor functional outcome at 3 (OR 1.04; CI 1.00-1.07, p=0.03) and 6months (1.04; CI 1.01-1.08, p=0.02). However, there was no association between episodic ICP data and outcome. Conclusions: These results suggest that pressure time dose measurement of intracranial pressure may be used to predict outcome in severe traumatic brain injury and may be a candidate biomarker in this disease. Springer Science+Business Media New York, 2012 Traumatic brain injury nationallicence Head trauma nationallicence Trauma nationallicence Intracranial pressure nationallicence Critical care nationallicence Sheth Kevin Department of Neurology, University of Maryland School of Medicine, 110 S. Paca Street, 3rd Floor, 21201, Baltimore, MD, USA aut Stein Deborah Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, USA aut Aarabi Bizhan Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, USA aut Hu Peter Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, USA aut Kufera Joseph Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, USA aut Scalea Thomas Department of Surgery, University of Maryland School of Medicine, Baltimore, USA aut Hanley Daniel Brain Injury Outcomes Program, Johns Hopkins Medical Institutions, Baltimore, USA aut Neurocritical Care Humana Press Inc 18/1(2013-02-01), 26-32 1541-6933 18:1<26 2013 18 12028 https://doi.org/10.1007/s12028-012-9780-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9780-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sheth Kevin Department of Neurology, University of Maryland School of Medicine, 110 S. Paca Street, 3rd Floor, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Stein Deborah Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, USA aut NATIONALLICENCE 700 1- Aarabi Bizhan Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, USA aut NATIONALLICENCE 700 1- Hu Peter Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, USA aut NATIONALLICENCE 700 1- Kufera Joseph Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, USA aut NATIONALLICENCE 700 1- Scalea Thomas Department of Surgery, University of Maryland School of Medicine, Baltimore, USA aut NATIONALLICENCE 700 1- Hanley Daniel Brain Injury Outcomes Program, Johns Hopkins Medical Institutions, Baltimore, USA aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/1(2013-02-01), 26-32 1541-6933 18:1<26 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer