naa a22 4500 510800068 CHVBK 20180411083351.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12028-013-9823-4 doi (NATIONALLICENCE)springer-10.1007/s12028-013-9823-4 Clinical Outcomes Following Prolonged Refractory Status Epilepticus (PRSE) [Elektronische Daten] [R. Kilbride, A. Reynolds, J. Szaflarski, L. Hirsch] Background: To define the clinical profile and outcome of patients in prolonged refractory status epilepticus (PRSE), and investigate possible predictors of outcome. Methods: We reviewed 63 consecutive patients with PRSE cared for in the medical and neurointensive care units of three academic medical centers over a 9-year period. For this multi-center retrospective cohort study, PRSE was defined as SE that persisted despite at least 1week of induced coma. Variables examined for their relationship to outcome included etiology, EEG, neuroimaging, and age. Results: Forty-two (66%) of 63 patients in PRSE survived to discharge from hospitalization. Fourteen (22%) patients had a good outcome (mRS≤3) at last available follow up (at least 6months post-PRSE). Of these, 6 (10%) individuals had no significant disability and were able to carry out all usual activities (mRS=1). Normal neuroimaging and a reactive EEG at onset of PRSE were associated with good outcome. Good or excellent clinical outcomes were possible in patients in PRSE for up to 79days, and in patients up to 69years old. Conclusions: Good outcome is not unusual in PRSE, including in some older patients, in a variety of diagnoses, and despite months of coma. Springer Science+Business Media New York, 2013 Status epilepticus nationallicence PRSE nationallicence Neuro ICU nationallicence Outcomes nationallicence Kilbride R. Division of Epilepsy, Massachusetts General Hospital, 55 Fruit St., 02114, Boston, MA, USA aut Reynolds A. Comprehensive Epilepsy Center, Neurological Institute, 710 W 168th St., 10032, New York, NY, USA aut Szaflarski J. Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, 35294, Birmingham, AL, USA aut Hirsch L. Division of Epilepsy and EEG, Comprehensive Epilepsy Center, Critical Care EEG Program, Yale University School of Medicine, 15 York St, LLCI-714, 06510, New Haven, CT, USA aut Neurocritical Care Humana Press Inc 18/3(2013-06-01), 374-385 1541-6933 18:3<374 2013 18 12028 https://doi.org/10.1007/s12028-013-9823-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-013-9823-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kilbride R. Division of Epilepsy, Massachusetts General Hospital, 55 Fruit St., 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Reynolds A. Comprehensive Epilepsy Center, Neurological Institute, 710 W 168th St., 10032, New York, NY, USA aut NATIONALLICENCE 700 1- Szaflarski J. Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, 35294, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Hirsch L. Division of Epilepsy and EEG, Comprehensive Epilepsy Center, Critical Care EEG Program, Yale University School of Medicine, 15 York St, LLCI-714, 06510, New Haven, CT, USA aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/3(2013-06-01), 374-385 1541-6933 18:3<374 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer