naa a22 4500 510800076 CHVBK 20180411083351.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12028-012-9805-y doi (NATIONALLICENCE)springer-10.1007/s12028-012-9805-y Hyponatremia and Brain Injury: Historical and Contemporary Perspectives [Elektronische Daten] [Matthew Kirkman, Angelique Albert, Ahmed Ibrahim, Doris Doberenz] Hyponatremia is common in neurocritical care patients and is associated with significant morbidity and mortality. Despite decades of research into the syndrome of inappropriate antidiuretic hormone (SIADH) and cerebral salt wasting (CSW), their underlying pathophysiological mechanisms are still not fully understood. This paper reviews the history behind our understanding of hyponatremia in patients with neurologic injury, including the first reports of CSW and SIADH, and current and future challenges to diagnosis and management in this setting. Such challenges include distinguishing CSW, SIADH, and hypovolemic hyponatremia due to a normal pressure natriuresis from the administration of large volumes of fluids, and hyponatremia due to certain medications used in the neurocritical care population. Potential treatments for hyponatremia include mineralocorticoids and vasopressin 2 receptor antagonists, but further work is required to validate their usage. Ultimately, a greater understanding of the pathophysiological mechanisms underlining hyponatremia in neurocritical care patients remains our biggest obstacle to optimizing patient outcomes in this challenging population. Springer Science+Business Media New York, 2012 Brain injury nationallicence Cerebral salt wasting nationallicence Hyponatremia nationallicence Syndrome of inappropriate antidiuretic hormone secretion nationallicence Subarachnoid hemorrhage nationallicence Kirkman Matthew Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut Albert Angelique Neurointensive Care Unit, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Salford, UK aut Ibrahim Ahmed Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut Doberenz Doris Intensive Care Unit, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK aut Neurocritical Care Humana Press Inc 18/3(2013-06-01), 406-416 1541-6933 18:3<406 2013 18 12028 https://doi.org/10.1007/s12028-012-9805-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9805-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kirkman Matthew Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Albert Angelique Neurointensive Care Unit, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Salford, UK aut NATIONALLICENCE 700 1- Ibrahim Ahmed Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Doberenz Doris Intensive Care Unit, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/3(2013-06-01), 406-416 1541-6933 18:3<406 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer