naa a22 4500 510800130 CHVBK 20180411083351.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12028-012-9813-y doi (NATIONALLICENCE)springer-10.1007/s12028-012-9813-y Troponin Elevation in Subarachnoid Hemorrhage Does not Impact In-hospital Mortality [Elektronische Daten] [Manisha Gupte, Sayona John, Shyam Prabhakaran, Vivien Lee] Background: Cardiac dysfunction is a well-known complication of subarachnoid hemorrhage (SAH). Our objective was to determine the frequency of troponin abnormalities in SAH and determine its impact on in-hospital mortality. Methods: With IRB approval, we retrospectively reviewed 225 consecutive SAH patients admitted to our institution from August 1, 2006 to June 1, 2009. Traumatic SAH patients were excluded. Data were collected on demographics, Hunt and Hess score (HH), in-hospital mortality, and peak troponin values on admission. CT images were independently reviewed and graded by the study neurologist for Fisher grade (FG) and the presence of intraventricular hemorrhage (IVH). Results: Among the 225 SAH patients, the mean age was 57.3years (range, 21-90). The majority of patients were female (67%), FG 3 (75%), and had IVH (62%). Among the 201 patients with troponin I values, the mean troponin level was 0.93 (range, 0.01-25.8ng/mL) and 47 (23%) had elevated troponin I levels. In unadjusted analysis, elevated troponin I level was significantly associated with in-hospital mortality. With multivariable logistic regression adjusting for age, HH, FG, and IVH, elevated troponin I level was no longer associated with in-hospital mortality (p. 0.34). In multivariate analysis, the independent predictors of in-mortality were age and severe grade HH (4-5). Conclusions: Troponin I elevation after SAH is not an independent predictor of in-hospital mortality. Springer Science+Business Media New York, 2012 Subarachnoid hemorrhage nationallicence Troponin nationallicence Mortality nationallicence Gupte Manisha Department of Neurological Sciences, Section of Cerebrovascular Disease and Neurological Critical Care, Rush University Medical Center, 1725W. Harrison St #1121, 60612, Chicago, IL, US aut John Sayona Department of Neurological Sciences, Section of Cerebrovascular Disease and Neurological Critical Care, Rush University Medical Center, 1725W. Harrison St #1121, 60612, Chicago, IL, US aut Prabhakaran Shyam Department of Neurology, Northwestern University, 60611, Chicago, IL, US aut Lee Vivien Department of Neurological Sciences, Section of Cerebrovascular Disease and Neurological Critical Care, Rush University Medical Center, 1725W. Harrison St #1121, 60612, Chicago, IL, US aut Neurocritical Care Humana Press Inc 18/3(2013-06-01), 368-373 1541-6933 18:3<368 2013 18 12028 https://doi.org/10.1007/s12028-012-9813-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9813-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gupte Manisha Department of Neurological Sciences, Section of Cerebrovascular Disease and Neurological Critical Care, Rush University Medical Center, 1725W. Harrison St #1121, 60612, Chicago, IL, US aut NATIONALLICENCE 700 1- John Sayona Department of Neurological Sciences, Section of Cerebrovascular Disease and Neurological Critical Care, Rush University Medical Center, 1725W. Harrison St #1121, 60612, Chicago, IL, US aut NATIONALLICENCE 700 1- Prabhakaran Shyam Department of Neurology, Northwestern University, 60611, Chicago, IL, US aut NATIONALLICENCE 700 1- Lee Vivien Department of Neurological Sciences, Section of Cerebrovascular Disease and Neurological Critical Care, Rush University Medical Center, 1725W. Harrison St #1121, 60612, Chicago, IL, US aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/3(2013-06-01), 368-373 1541-6933 18:3<368 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer