naa a22 4500 510800289 CHVBK 20180411083352.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12028-012-9810-1 doi (NATIONALLICENCE)springer-10.1007/s12028-012-9810-1 Outcome of Poor-Grade Subarachnoid Hemorrhage as Determined by Biomarkers of Glucose Cerebral Metabolism [Elektronische Daten] [Gleicy Barcelos, Yannick Tholance, Sebastien Grousson, Bernard Renaud, Armand Perret-Liaudet, Frederic Dailler, Luc Zimmer] Purpose: The aim of this study was to determine if the measurement of blood biomarkers of glucose cerebral metabolism, performed with retrograde jugular catheter, could predict the outcome of poor-grade aneurysmal subarachnoid hemorrhage (aSAH) patients. Methods: This study was conducted in 68 poor-grade aSAH patients. A total of 4,024 blood samples obtained from jugular and radial catheters were analyzed for glucose, lactate, and oxygen content every 8h for 10±0.5days. Metabolic ratio (MR) and lactate-oxygen index (LOI) were obtained by ratios using arterio-jugular differences. Functional outcome was evaluated at 12months with the Glasgow Outcome Scale. Results: Outcome was unfavorable in 40 patients. In this group of patients, the MR was significantly lower (p<0.0001) and the LOI was significantly higher (p=0.0001) than in the group with favorable outcome. The MR cutoff value, below which the patients are likely to have an unfavorable outcome, was determined to be 3.35. More interestingly, the data obtained in this study demonstrated that the patients achieving an unfavorable outcome were distinguished from those with a favorable outcome by having at least three events of MR inferior to 3.35 (sensitivity=90%, specificity=82.1%). Moreover, in patients who developed cerebral vasospasm, we observed a significant decrease in the MR. Conclusion: Our data provide additional support to the view that the MR is a reliable marker for predicting the outcome of poor-grade aSAH patients. Prospective studies are needed to confirm its value in multimodal monitoring. Springer Science+Business Media New York, 2013 Cerebral ischemia nationallicence Glucose metabolism nationallicence Hyperglycolysis nationallicence Neurologic outcome nationallicence Subarachnoid hemorrhage nationallicence Barcelos Gleicy BioRaN Team, Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, University Lyon 1, Lyon, France aut Tholance Yannick Neurochemistry Unit, Department of Biochemistry, Neurological Hospital, Hospices Civils de Lyon, Lyon, France aut Grousson Sebastien Intensive Care Unit, Neurological Hospital, Hospices Civils de Lyon, Lyon, France aut Renaud Bernard Neurochemistry Unit, Department of Biochemistry, Neurological Hospital, Hospices Civils de Lyon, Lyon, France aut Perret-Liaudet Armand BioRaN Team, Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, University Lyon 1, Lyon, France aut Dailler Frederic Intensive Care Unit, Neurological Hospital, Hospices Civils de Lyon, Lyon, France aut Zimmer Luc BioRaN Team, Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, University Lyon 1, Lyon, France aut Neurocritical Care Humana Press Inc 18/2(2013-04-01), 234-244 1541-6933 18:2<234 2013 18 12028 https://doi.org/10.1007/s12028-012-9810-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9810-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barcelos Gleicy BioRaN Team, Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, University Lyon 1, Lyon, France aut NATIONALLICENCE 700 1- Tholance Yannick Neurochemistry Unit, Department of Biochemistry, Neurological Hospital, Hospices Civils de Lyon, Lyon, France aut NATIONALLICENCE 700 1- Grousson Sebastien Intensive Care Unit, Neurological Hospital, Hospices Civils de Lyon, Lyon, France aut NATIONALLICENCE 700 1- Renaud Bernard Neurochemistry Unit, Department of Biochemistry, Neurological Hospital, Hospices Civils de Lyon, Lyon, France aut NATIONALLICENCE 700 1- Perret-Liaudet Armand BioRaN Team, Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, University Lyon 1, Lyon, France aut NATIONALLICENCE 700 1- Dailler Frederic Intensive Care Unit, Neurological Hospital, Hospices Civils de Lyon, Lyon, France aut NATIONALLICENCE 700 1- Zimmer Luc BioRaN Team, Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, University Lyon 1, Lyon, France aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/2(2013-04-01), 234-244 1541-6933 18:2<234 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer