naa a22 4500 510800386 CHVBK 20180411083352.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12028-012-9762-5 doi (NATIONALLICENCE)springer-10.1007/s12028-012-9762-5 Mild Prolonged Hypothermia for Large Intracerebral Hemorrhage [Elektronische Daten] [Dimitre Staykov, Ingrid Wagner, Bastian Volbers, Arnd Doerfler, Stefan Schwab, Rainer Kollmar] Background: Perihemorrhagic edema (PHE) develops after intracerebral hemorrhage (ICH). It can worsen the clinical situation by its additional mass effect. Therapeutic hypothermia (TH) might be an effective method to control PHE, but has not been sufficiently studied in ICH patients. Methods: We report data on n=25 consecutive patients with large supratentorial ICH (volume>25ml) who were treated by mild TH of 35°C for 8-10days. Body temperature was controlled by endovascular cooling catheters. We followed the clinical course during hospital stay and measured volumes of ICH and PHE in regularly performed serial cranial computed tomography. Outcome was assessed after 3 and 12months. These data were compared to a historical group of n=25 patients with large ICH. Results: While PHE continuously increased in the historical control group up to day 10, PHE volumes in the hypothermia group remained stable. There was a significant difference from day 3 after symptom onset. Shivering (36%) and pneumonia (96%) were the most frequent complications during TH. Mortality rate was 8.3% in TH versus 16.7% in the control group after 3months and 28 versus 44% after 1year. Conclusions: These data support the promising results of our first case series on TH in large ICH. TH prevents the development of PHE and its complications. Side effects of TH appeared often, but could be treated sufficiently. Therefore, TH might represent a new therapy for PHE after large ICH, but has to be further tested in randomized trials. Springer Science+Business Media, LLC, 2012 Intracerebral hemorrhage nationallicence Perihemorrhagic edema nationallicence Hypothermia nationallicence Staykov Dimitre Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut Wagner Ingrid Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut Volbers Bastian Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut Doerfler Arnd Department of Neuroradiology, University of Erlangen-Nuremberg, Erlangen, Germany aut Schwab Stefan Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut Kollmar Rainer Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut Neurocritical Care Humana Press Inc 18/2(2013-04-01), 178-183 1541-6933 18:2<178 2013 18 12028 https://doi.org/10.1007/s12028-012-9762-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9762-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Staykov Dimitre Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Wagner Ingrid Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Volbers Bastian Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Doerfler Arnd Department of Neuroradiology, University of Erlangen-Nuremberg, Erlangen, Germany aut NATIONALLICENCE 700 1- Schwab Stefan Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Kollmar Rainer Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/2(2013-04-01), 178-183 1541-6933 18:2<178 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer