naa a22 4500 510800394 CHVBK 20180411083352.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12028-012-9803-0 doi (NATIONALLICENCE)springer-10.1007/s12028-012-9803-0 Long-Term Outcomes of Post-Thrombolytic Intracerebral Hemorrhage in Ischemic Stroke Patients [Elektronische Daten] [Kiersten Norby, Farhan Siddiq, Malik Adil, Saqib Chaudhry, Adnan Qureshi] Background: Intracerebral hemorrhage (ICH) is an infrequent complication of intravenous recombinant tissue plasminogen activator (rt-PA) for the treatment of acute stroke. However, such ICH is an important reason for withdrawal of care because of lack of adequate data regarding long-term patient outcomes. Objective: To report the long-term outcomes in patients with post-thrombolytic ICH. Methods: We analyzed patient data from a randomized, placebo-controlled trial in patients with ischemic stroke presenting within 3h of symptom onset. Baseline clinical characteristics and outcomes defined by modified Rankin scale (mRS) were ascertained at 3, 6, and 12months after treatment in patients who suffered from post-thrombolytic ICH. Favorable outcome was defined by mRS of 0-3 and unfavorable outcome by mRS of 4-6 at 1year. Results: A total of 48 patients suffered post-thrombolytic ICH in the trial. Fourteen patients had favorable outcomes and 34 patients had unfavorable outcomes. Clinical characteristics did not have an impact on patient outcomes at 12months. Patients with unfavorable outcomes were more likely to have an National Institutes of Health Stroke Scale (NIHSS) score ≥20 at 7-10days after treatment (64 vs. 7%, p<0.0009). Patients with unfavorable outcomes were more likely to have a worsening of NIHSS score of >4 points at 7-10days from their baseline NIHSS (44 vs. 0%, p=0.0006). Conclusion: Approximately 30% of patients with post-thrombolytic ICH have favorable outcomes at 1year which does not support early withdrawal of care. Ascertainment of NIHSS score and worsening of NIHSS score at 7-10days may be necessary for accurate prognostic stratification. Springer Science+Business Media New York, 2012 Intracerebral hemorrhage nationallicence Ischemic stroke nationallicence Thrombolytic nationallicence Long-term outcome nationallicence Modified Rankin score nationallicence Barthel index nationallicence Norby Kiersten Zeenat Qureshi Stroke Research Center, Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA aut Siddiq Farhan Zeenat Qureshi Stroke Research Center, Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA aut Adil Malik Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN, USA aut Chaudhry Saqib Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN, USA aut Qureshi Adnan Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN, USA aut Neurocritical Care Humana Press Inc 18/2(2013-04-01), 170-177 1541-6933 18:2<170 2013 18 12028 https://doi.org/10.1007/s12028-012-9803-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12028-012-9803-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Norby Kiersten Zeenat Qureshi Stroke Research Center, Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Siddiq Farhan Zeenat Qureshi Stroke Research Center, Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Adil Malik Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Chaudhry Saqib Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Qureshi Adnan Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Neurocritical Care Humana Press Inc 18/2(2013-04-01), 170-177 1541-6933 18:2<170 2013 18 12028 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer