naa a22 4500 510805485 CHVBK 20180411083416.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12576-012-0237-4 doi (NATIONALLICENCE)springer-10.1007/s12576-012-0237-4 Peroxiredoxins and sports: new insights on the antioxidative defense [Elektronische Daten] [Christian Brinkmann, Klara Brixius] Peroxiredoxins (PRDXs) are multifunctional proteins that have recently received much attention. They are part of the endogenous antioxidative capacity and function as efficient scavengers, especially for hydrogen peroxides. Studies show that physical training can induce an upregulation of PRDX isoform contents in the long term. This might help counteract chronic diseases that are causally linked to a high amount of free radicals, e.g., diabetes mellitus. Furthermore, it has been demonstrated that PRDX can overoxidize under pathological conditions during acute exercise. Overoxidized PRDXs could be useful because they act as protective chaperones. Taken together, it can be speculated that physical activity has a positive effect on the PRDX system and thereby prevents cells from free radical-induced damage. The Physiological Society of Japan and Springer Japan, 2012 Peroxiredoxins nationallicence Antioxidative defense nationallicence Sports nationallicence Physical activity nationallicence Brinkmann Christian Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany aut Brixius Klara Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany aut The Journal of Physiological Sciences Springer Japan 63/1(2013-01-01), 1-5 1880-6546 63:1<1 2013 63 12576 https://doi.org/10.1007/s12576-012-0237-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-012-0237-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brinkmann Christian Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany aut NATIONALLICENCE 700 1- Brixius Klara Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/1(2013-01-01), 1-5 1880-6546 63:1<1 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer