naa a22 4500 510805523 CHVBK 20180411083416.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12576-012-0229-4 doi (NATIONALLICENCE)springer-10.1007/s12576-012-0229-4 Regional differences in serotonin content in the nucleus of the solitary tract of male rats after hypovolemia produced by polyethylene glycol [Elektronische Daten] [J. Curtis, Michael Anderson, Kathleen Curtis] Serotonin (5-HT) has been implicated in centrally mediated compensatory responses to volume loss in rats. Accordingly, we hypothesized that slowly developing, non-hypotensive hypovolemia increases serotonin in the hindbrain nucleus of the solitary tract (NTS). We produced volume loss in adult male rats by administering hyperoncotic polyethylene glycol (PEG) and then assessed 5-HT levels in the NTS using measurements of tissue 5-HT content or 5-HT immunohistochemistry. The results show selective increases of 5-HT in the caudal NTS after PEG treatment, but no change in the primary 5-HT metabolite, 5-HIAA. Moreover, the intensity of 5-HT immunolabeled fibers in the caudal NTS was increased after PEG treatment. These findings suggest that, after PEG-induced hypovolemia, 5-HT accumulates in neural elements in the caudal NTS. We propose that this accumulation is attributable to an initial release of 5-HT that then acts at presynaptic autoreceptors to inhibit subsequent 5-HT release. The Physiological Society of Japan and Springer, 2012 Baroreflex pathway nationallicence Hemorrhage nationallicence 5-HIAA nationallicence Norepinephrine nationallicence Curtis J. Department of Pharmacology and Physiology, Oklahoma State University-Center for Health Sciences, 1111 West 17th St, 74107-1898, Tulsa, OK, USA aut Anderson Michael Department of Pharmacology and Physiology, Oklahoma State University-Center for Health Sciences, 1111 West 17th St, 74107-1898, Tulsa, OK, USA aut Curtis Kathleen Department of Pharmacology and Physiology, Oklahoma State University-Center for Health Sciences, 1111 West 17th St, 74107-1898, Tulsa, OK, USA aut The Journal of Physiological Sciences Springer Japan 63/1(2013-01-01), 39-46 1880-6546 63:1<39 2013 63 12576 https://doi.org/10.1007/s12576-012-0229-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-012-0229-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Curtis J. Department of Pharmacology and Physiology, Oklahoma State University-Center for Health Sciences, 1111 West 17th St, 74107-1898, Tulsa, OK, USA aut NATIONALLICENCE 700 1- Anderson Michael Department of Pharmacology and Physiology, Oklahoma State University-Center for Health Sciences, 1111 West 17th St, 74107-1898, Tulsa, OK, USA aut NATIONALLICENCE 700 1- Curtis Kathleen Department of Pharmacology and Physiology, Oklahoma State University-Center for Health Sciences, 1111 West 17th St, 74107-1898, Tulsa, OK, USA aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/1(2013-01-01), 39-46 1880-6546 63:1<39 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer