naa a22 4500 510805620 CHVBK 20180411083417.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12576-013-0282-7 doi (NATIONALLICENCE)springer-10.1007/s12576-013-0282-7 Effect of high sustained +Gz stress on myocardial mitochondrial ultrastructure, respiratory function, and antioxidant capacity in rats [Elektronische Daten] [Liang-En Chen, Feng Wu, Yimei Xin, Andong Zhao, Xiqing Sun, Hao Zhan] Exposure to high sustained positive acceleration (+Gz) is known to have a pathophysiological effect on the heart of the rat. As critical regulators of cardiac myocyte survival and death, mitochondria may be crucially involved in +Gz-induced pathogenesis. It was, therefore, of interest to investigate myocardial mitochondrial ultrastructure, respiratory function, and antioxidant capacity in rats after exposure to +10Gz for 5min. The results showed that high +Gz stress could damage mitochondrial ultrastructure; this was apparent from swollen, degenerated, and reduced mitochondria, and mitochondrial cristae broken or disappeared. This resulted in significant changes of quantitative indicators of mitochondria morphometry, for example increased surface density, volume density, average volume, and average surface area, and reduced numerical density. The studies also revealed that exposure to +Gz stress induced dysfunction of the mitochondrial respiratory chain, reduced the activity of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase), and increased malondialdehyde content. We thus conclude that high +Gz stress not only damaged mitochondrial ultrastructure but also impaired respiratory function and antioxidant capacity. The Physiological Society of Japan and Springer Japan, 2013 Positive acceleration nationallicence Myocardial mitochondria nationallicence Ultrastructure nationallicence Respiratory function nationallicence Antioxidant capacity nationallicence Chen Liang-En Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut Wu Feng Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut Xin Yimei Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut Zhao Andong Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut Sun Xiqing Department of Aerospace Biodynamics, Faculty of Aerospace Medicine, Fourth Military Medical University, No. 17 Chang Le Xi Lu, Xi'an, China aut Zhan Hao Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut The Journal of Physiological Sciences Springer Japan 63/6(2013-11-01), 457-464 1880-6546 63:6<457 2013 63 12576 https://doi.org/10.1007/s12576-013-0282-7 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-013-0282-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Liang-En Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut NATIONALLICENCE 700 1- Wu Feng Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut NATIONALLICENCE 700 1- Xin Yimei Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut NATIONALLICENCE 700 1- Zhao Andong Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut NATIONALLICENCE 700 1- Sun Xiqing Department of Aerospace Biodynamics, Faculty of Aerospace Medicine, Fourth Military Medical University, No. 17 Chang Le Xi Lu, Xi'an, China aut NATIONALLICENCE 700 1- Zhan Hao Aviation Physiological Laboratory, Institute of Aviation Medicine, Air Force, No. 28 Fucheng Road, Beijing, China aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/6(2013-11-01), 457-464 1880-6546 63:6<457 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer