naa a22 4500 510805671 CHVBK 20180411083417.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12576-013-0259-6 doi (NATIONALLICENCE)springer-10.1007/s12576-013-0259-6 Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors [Elektronische Daten] [Kathrine Redington, Tara Disenhouse, Jing Li, Can Wei, Xiaojing Dai, Rachel Gladstone, Cedric Manlhiot, Andrew Redington] Previous studies have shown that electroacupuncture (EA) can induce cardioprotection against ischemia-reperfusion (IR) injury, but its mechanisms are incompletely understood. We have previously shown that several other forms of remote preconditioning of the heart work, at least in part, via the release of circulating cardioprotective factors into the bloodstream, that can be dialyzed and subsequently shown to reduce IR injury in isolated hearts. We used the same methods to assess whether EA leads to similar humoral cardioprotection. EA rabbits were subjected to 60min of bilateral stimulation at the Neiguan point, following which their blood was drawn, dialyzed, and used to perfuse hearts in Langendorff preparation and subsequently subjected to 60min of global ischemia and 120min of reperfusion. Compared to controls, dialysate from EA animals led to significant reduction in infarct size and improved functional recovery. The degree of cardioprotection was no different to that seen in animals randomized to receive remote preconditioning using transient limb ischemia (4 cycles of 5min ischemia/5min reperfusion). These results suggest that EA recapitulates the cardioprotection achieved by remote preconditioning, by similarly leading to release of circulating cardioprotective factors. The Physiological Society of Japan and Springer Japan, 2013 Remote preconditioning nationallicence Electroacupuncture nationallicence Cardioprotection nationallicence Redington Kathrine Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut Disenhouse Tara Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut Li Jing Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut Wei Can Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut Dai Xiaojing Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut Gladstone Rachel Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut Manlhiot Cedric Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut Redington Andrew Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut The Journal of Physiological Sciences Springer Japan 63/3(2013-05-01), 219-223 1880-6546 63:3<219 2013 63 12576 https://doi.org/10.1007/s12576-013-0259-6 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-013-0259-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Redington Kathrine Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Disenhouse Tara Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Li Jing Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Wei Can Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Dai Xiaojing Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Gladstone Rachel Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Manlhiot Cedric Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Redington Andrew Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, M5G1X8, Toronto, ON, Canada aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/3(2013-05-01), 219-223 1880-6546 63:3<219 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer