naa a22 4500 51080568X CHVBK 20180411083417.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12576-013-0258-7 doi (NATIONALLICENCE)springer-10.1007/s12576-013-0258-7 The effect of androgen on the retention of extinction memory after conditioned taste aversion in mice [Elektronische Daten] [Ema Suzuki, Hiroko Eda-Fujiwara, Ryohei Satoh, Rika Saito, Takenori Miyamoto] Conditioned taste aversion (CTA) induced by the application of a novel taste such as sodium saccharin (Sac) as the conditioned stimulus (CS) and a malaise-inducing agent as the unconditioned stimulus (US), results in acquisition of CTA memory to Sac. In contrast, CTA is extinguished by repeated presentations of the CS without the US, resulting in acquisition of the extinction memory. We examined the effects of androgenic hormones on acquisition and retention of extinction memory in mice. We gonadectomized sexually immature mice and continuously administered androgens to these animals. After sexual maturation, the mice underwent a conditioning period followed by an extinction period. Retrieval tests revealed that the androgen-treated group showed significantly greater retention of extinction memory than the non-treated group 5weeks later, whereas such significant difference was not observed in acquisition of extinction memory. These results demonstrate the enhancing effect of androgens on retention of extinction memory. The Physiological Society of Japan and Springer Japan, 2013 Acquisition nationallicence Retention nationallicence Androgen nationallicence Conditioned taste aversion memory nationallicence Extinction memory nationallicence Suzuki Ema Laboratory of Behavioral Neuroscience, Division of Material and Biological Sciences, Graduate School of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, 112-8681, Tokyo, Japan aut Eda-Fujiwara Hiroko Japan Society for the Promotion of Science, Chiyoda-ku, 102-8472, Tokyo, Japan aut Satoh Ryohei Department of Physiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0374, Sagamihara, Kanagawa, Japan aut Saito Rika Laboratory of Behavioral Neuroscience, Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, 112-8681, Tokyo, Japan aut Miyamoto Takenori Laboratory of Behavioral Neuroscience, Division of Material and Biological Sciences, Graduate School of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, 112-8681, Tokyo, Japan aut The Journal of Physiological Sciences Springer Japan 63/3(2013-05-01), 171-181 1880-6546 63:3<171 2013 63 12576 https://doi.org/10.1007/s12576-013-0258-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-013-0258-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki Ema Laboratory of Behavioral Neuroscience, Division of Material and Biological Sciences, Graduate School of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, 112-8681, Tokyo, Japan aut NATIONALLICENCE 700 1- Eda-Fujiwara Hiroko Japan Society for the Promotion of Science, Chiyoda-ku, 102-8472, Tokyo, Japan aut NATIONALLICENCE 700 1- Satoh Ryohei Department of Physiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0374, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Saito Rika Laboratory of Behavioral Neuroscience, Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, 112-8681, Tokyo, Japan aut NATIONALLICENCE 700 1- Miyamoto Takenori Laboratory of Behavioral Neuroscience, Division of Material and Biological Sciences, Graduate School of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, 112-8681, Tokyo, Japan aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/3(2013-05-01), 171-181 1880-6546 63:3<171 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer