naa a22 4500 510805779 CHVBK 20180411083417.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12576-013-0264-9 doi (NATIONALLICENCE)springer-10.1007/s12576-013-0264-9 Platelet monoamine oxidase-A activity and aging: effect of carnosine [Elektronische Daten] [S. Banerjee, M. Poddar] Platelet mitochondrial MAO-A activity of male albino rats (Wistar strain) was significantly inhibited with an inhibition of its only V max during aging. This age-induced inhibition of platelet MAO-A activity became reversed following the application of higher dosages (2.0-2.5μg/kg/day, i.t. for 21 consecutive days) of carnosine. Though carnosine at lower dosage (0.5μg/kg/day, i.t. for 21 consecutive days) was ineffective to platelet mitochondrial MAO-A activity in both young and aged rats, at higher dosages (2.0-2.5μg/kg/day, i.t. for 21 consecutive days) under similar condition this enzyme activity was significantly enhanced. Carnosine at 1.0μg/kg/day, i.t. for 21 consecutive days significantly enhanced MAO-A activity only in aged (18 and 24months) rats. These results suggest that carnosine withdraws the aging-induced inhibition of mammalian blood platelet MAO-A activity and restores its activity towards that (MAO-A activity) observed in young mammalian blood platelets. The Physiological Society of Japan and Springer Japan, 2013 Blood platelet nationallicence Monoamine oxidase-A (MAO-A) nationallicence Aging nationallicence Carnosine nationallicence Banerjee S. Department of Biochemistry, University of Calcutta, 35, B.C. Road, 700 019, Kolkata, India aut Poddar M. Department of Biochemistry, University of Calcutta, 35, B.C. Road, 700 019, Kolkata, India aut The Journal of Physiological Sciences Springer Japan 63/4(2013-07-01), 279-285 1880-6546 63:4<279 2013 63 12576 https://doi.org/10.1007/s12576-013-0264-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-013-0264-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Banerjee S. Department of Biochemistry, University of Calcutta, 35, B.C. Road, 700 019, Kolkata, India aut NATIONALLICENCE 700 1- Poddar M. Department of Biochemistry, University of Calcutta, 35, B.C. Road, 700 019, Kolkata, India aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/4(2013-07-01), 279-285 1880-6546 63:4<279 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer