naa a22 4500 510805809 CHVBK 20180411083417.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12576-013-0265-8 doi (NATIONALLICENCE)springer-10.1007/s12576-013-0265-8 Prolonged exposure to a low-dose of bisphenol A increases spontaneous motor activity in adult male rats [Elektronische Daten] [Kazuo Nojima, Tomoyo Takata, Hiroshi Masuno] We investigated the effects of bisphenol A (BPA), an environmental endocrine-disrupting chemical, on spontaneous motor activity in adult male rats. The rats were implanted intraperitoneally with mini-osmotic pumps containing either BPA (50μg/kg body weight per day) in sesame oil (BPA-treated group) or sesame oil only (vehicle-treated group). Spontaneous motor activity during a 24-h period was measured over 5days from day 9 to day 13 after implantation using an animal movement analysis system. Spontaneous motor activity during the last 2 h of the dark phase and during the first 1-h of the light phase was increased in the BPA-treated group. Total spontaneous motor activity during the 12-h light phase, but not the 12-h dark phase, was higher in the BPA-treated group than in the vehicle-treated group. These findings suggest that BPA may induce hyperactivity in adult male rats during the 12-h light phase, especially during the 2 h immediately preceding sleep-onset and 1 h immediately following sleep-onset. The Physiological Society of Japan and Springer Japan, 2013 Bisphenol A nationallicence Low dose nationallicence Spontaneous motor activity nationallicence Light phase nationallicence Adult male rats nationallicence Nojima Kazuo Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, 791-2101, Tobe-cho, Iyo-gun, Ehime, Japan aut Takata Tomoyo Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, 791-2101, Tobe-cho, Iyo-gun, Ehime, Japan aut Masuno Hiroshi Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, 791-2101, Tobe-cho, Iyo-gun, Ehime, Japan aut The Journal of Physiological Sciences Springer Japan 63/4(2013-07-01), 311-315 1880-6546 63:4<311 2013 63 12576 https://doi.org/10.1007/s12576-013-0265-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-013-0265-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nojima Kazuo Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, 791-2101, Tobe-cho, Iyo-gun, Ehime, Japan aut NATIONALLICENCE 700 1- Takata Tomoyo Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, 791-2101, Tobe-cho, Iyo-gun, Ehime, Japan aut NATIONALLICENCE 700 1- Masuno Hiroshi Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Takooda, 791-2101, Tobe-cho, Iyo-gun, Ehime, Japan aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/4(2013-07-01), 311-315 1880-6546 63:4<311 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer