naa a22 4500 510805825 CHVBK 20180411083417.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12576-013-0256-9 doi (NATIONALLICENCE)springer-10.1007/s12576-013-0256-9 Alteration of neuromuscular transmissions in the hamster colon following the resolution of TNBS-induced colitis [Elektronische Daten] [Takahiko Shiina, Yam Gurung, Yuji Suzuki, Tadashi Takewaki, Yasutake Shimizu] The aim of this study was to determine whether trinitrobenzene sulfonic acid-induced colitis leads to alterations in enteric neuronal transmission in hamsters. We assessed the mechanical responses induced by the application of electrical field stimulation (EFS) in isolated segments of the distal colon. The EFS-induced relaxation and contraction were blocked by a nitric oxide synthase inhibitor and by the combination of antagonists for tachykinin NK1 and NK2 receptors and muscarinic acetylcholine receptors, respectively. The mechanical responses to EFS were attenuated in the inflamed colon at 7days and were recovered by 30days after inflammation treatment. In addition, we found that purinergic and opioidergic excitatory neural components are expressed following the resolution of colitis. These results suggest that colonic inflammation causes indiscriminate damage to enteric neurons but that neuronal components are restored and that new excitatory neural components, compensating for the contractile responses in smooth muscle after colitis, are expressed. The Physiological Society of Japan and Springer Japan, 2013 Colitis nationallicence Enteric nervous system nationallicence Gastrointestinal motility nationallicence Neuronal alteration nationallicence TNBS nationallicence Shiina Takahiko Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut Gurung Yam Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut Suzuki Yuji Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut Takewaki Tadashi Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut Shimizu Yasutake Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut The Journal of Physiological Sciences Springer Japan 63/4(2013-07-01), 241-249 1880-6546 63:4<241 2013 63 12576 https://doi.org/10.1007/s12576-013-0256-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-013-0256-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shiina Takahiko Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut NATIONALLICENCE 700 1- Gurung Yam Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut NATIONALLICENCE 700 1- Suzuki Yuji Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut NATIONALLICENCE 700 1- Takewaki Tadashi Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut NATIONALLICENCE 700 1- Shimizu Yasutake Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido 1-1, 501-1193, Gifu, Japan aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/4(2013-07-01), 241-249 1880-6546 63:4<241 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer