naa a22 4500 510805841 CHVBK 20180411083418.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12576-013-0263-x doi (NATIONALLICENCE)springer-10.1007/s12576-013-0263-x The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken [Elektronische Daten] [Morteza Zendehdel, Kasra Mokhtarpouriani, Vahab Babapour, Ali Baghbanzadeh, Maryam Pourrahimi, Shahin Hassanpour] The present study was designed to examine the effects of intracerebroventricular injection of para-chlorophenylalanine (PCPA) (cerebral serotonin depletive), fluoxetine (selective serotonin reuptake inhibitor), 8-OH-DPAT (5-HT1A autoreceptor agonist) and SB 242084 (5-HT2c receptor antagonist) on nociceptin/orphanin FQ (N/OFQ) induced feeding response in chickens. A guide cannula was surgically implanted into the lateral ventricle of chickens. Before the experiments, 3-h fasting periods had been given to all experimental birds. In experiment 1, chickens were injected with PCPA (1.5μg) followed by an N/OFQ injection (16nmol) intracerebroventricularly. In experiment 2, birds received fluoxetine (10μg) prior to the injection of N/OFQ. In experiment 3, chickens were administered with N/OFQ after the 8-OH-DPAT administration (15.25nmol). In experiment 4, birds were injected with SB 242084 (1.5μg) followed by an N/OFQ injection. Cumulative food intake was measured at 3h post injection. The results of this study show that N/OFQ increases food intake in broiler cockerels (P<0.05) and that this effect is amplified by pretreatment with PCPA and SB 242084 in an additive manner (P<0.05). The effect of N/OFQ is not changed by pretreatment with 8-OH-DPAT (P>0.05). Furthermore, the stimulatory effect of N/OFQ on food intake was significantly attenuated by pretreatment with fluoxetine. These results suggest that N/OFQ induced hyperphagia is mediated by serotonergic mechanisms, and possibly imply an interaction between N/OFQ and the serotonergic system (via 5-HT2C receptors) on food intake in chickens. The Physiological Society of Japan and Springer Japan, 2013 Nociceptin/orphanin FQ nationallicence Serotonergic system nationallicence Food intake nationallicence Chicken nationallicence Zendehdel Morteza Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut Mokhtarpouriani Kasra Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut Babapour Vahab Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut Baghbanzadeh Ali Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut Pourrahimi Maryam Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut Hassanpour Shahin Department of Physiology, Faculty of Veterinary Medicine, Islamic Azad University, Science and Research Branch, Tehran, Iran aut The Journal of Physiological Sciences Springer Japan 63/4(2013-07-01), 271-277 1880-6546 63:4<271 2013 63 12576 https://doi.org/10.1007/s12576-013-0263-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-013-0263-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zendehdel Morteza Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut NATIONALLICENCE 700 1- Mokhtarpouriani Kasra Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut NATIONALLICENCE 700 1- Babapour Vahab Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut NATIONALLICENCE 700 1- Baghbanzadeh Ali Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut NATIONALLICENCE 700 1- Pourrahimi Maryam Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran aut NATIONALLICENCE 700 1- Hassanpour Shahin Department of Physiology, Faculty of Veterinary Medicine, Islamic Azad University, Science and Research Branch, Tehran, Iran aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/4(2013-07-01), 271-277 1880-6546 63:4<271 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer