naa a22 4500 510805892 CHVBK 20180411083418.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12576-013-0272-9 doi (NATIONALLICENCE)springer-10.1007/s12576-013-0272-9 Effect of systemic α1-adrenergic receptor blockade on central blood pressure response during exercise [Elektronische Daten] [Jun Sugawara, R. Brothers, Peter Raven, Kazunobu Okazaki, Shigehiko Ogoh] The aortic pulse pressure (PP), which consists mainly of the incident wave and the reflected wave, has emerged as an important property of systemic blood vessels underlying the pathophysiology of cardiovascular disease. To determine the role of sympathetic nerve activity on the aortic PP response during dynamic exercise, we evaluated aortic hemodynamics during the right-leg knee-extension (40 and 60% of maximal voluntary contraction) in six young adults with and without the systemic α1-adrenergic receptor blockade using prazosin (1mg/20kg body weight). The use of prazosin attenuated the exercise-induced increase in aortic PP (P<0.05) but not in radial arterial PP. The amplitude of the reflected waves (via augmentation index) significantly decreased with the exercise and decreased more with the use of prazosin. These results suggest that during dynamic exercise the α1-adrenergic-mediated vasoconstrictor tone of the peripheral resistance vessels is manifestly involved in the magnitude of the reflected wave and the modulation of the aortic PP responses. The Physiological Society of Japan and Springer Japan, 2013 Arterial blood pressure nationallicence Wave reflection nationallicence Sympathetic activity nationallicence Sugawara Jun Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, 305-8566, Tsukuba, Japan aut Brothers R. The Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA aut Raven Peter The Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA aut Okazaki Kazunobu Research Center for Urban Health and Sports, Osaka City University, Sumiyoshi-ku, Osaka, Japan aut Ogoh Shigehiko The Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA aut The Journal of Physiological Sciences Springer Japan 63/5(2013-09-01), 389-393 1880-6546 63:5<389 2013 63 12576 https://doi.org/10.1007/s12576-013-0272-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-013-0272-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sugawara Jun Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, 305-8566, Tsukuba, Japan aut NATIONALLICENCE 700 1- Brothers R. The Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA aut NATIONALLICENCE 700 1- Raven Peter The Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA aut NATIONALLICENCE 700 1- Okazaki Kazunobu Research Center for Urban Health and Sports, Osaka City University, Sumiyoshi-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Ogoh Shigehiko The Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/5(2013-09-01), 389-393 1880-6546 63:5<389 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer