naa a22 4500 510805973 CHVBK 20180411083418.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12576-012-0247-2 doi (NATIONALLICENCE)springer-10.1007/s12576-012-0247-2 The effect of a physiological concentration of caffeine on the endurance of maximally and submaximally stimulated mouse soleus muscle [Elektronische Daten] [Jason Tallis, Rob James, Val Cox, Michael Duncan] The use of caffeine as an ergogenic aid to promote endurance has been widely studied, with human literature showing the greatest benefit during submaximal muscle activities. Recent evidence suggests that the acute treatment of skeletal muscle with physiological concentrations of caffeine (70μM maximum) will directly potentiate force production. The aims of the present study are: firstly, to assess the effects of a physiological concentration (70μM) of caffeine on endurance in maximally activated mouse soleus (relatively slow) muscle; and secondly, to examine whether endurance changes when muscle is activated submaximally during caffeine treatment. Maximally stimulated soleus muscle treated with 70μM caffeine resulted in a significant (17.6%) decrease in endurance. In contrast, at a submaximal stimulation frequency, caffeine treatment significantly prolonged endurance (by 19.2%). Findings are activation-dependent such that, during high frequency stimulation, caffeine accelerates fatigue, whereas, during low frequency stimulation, caffeine delays fatigue. The Physiological Society of Japan and Springer Japan, 2013 Activation level nationallicence Ergogenic aid nationallicence Endurance nationallicence Power nationallicence Isolated muscle nationallicence Skeletal muscle nationallicence Work loop nationallicence Tallis Jason Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, CV1 5FB, Coventry, UK aut James Rob Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, CV1 5FB, Coventry, UK aut Cox Val Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, CV1 5FB, Coventry, UK aut Duncan Michael Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, CV1 5FB, Coventry, UK aut The Journal of Physiological Sciences Springer Japan 63/2(2013-03-01), 125-132 1880-6546 63:2<125 2013 63 12576 https://doi.org/10.1007/s12576-012-0247-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12576-012-0247-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tallis Jason Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, CV1 5FB, Coventry, UK aut NATIONALLICENCE 700 1- James Rob Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, CV1 5FB, Coventry, UK aut NATIONALLICENCE 700 1- Cox Val Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, CV1 5FB, Coventry, UK aut NATIONALLICENCE 700 1- Duncan Michael Faculty of Health and Life Sciences, James Starley Building, Coventry University, Priory Street, CV1 5FB, Coventry, UK aut NATIONALLICENCE 773 0- The Journal of Physiological Sciences Springer Japan 63/2(2013-03-01), 125-132 1880-6546 63:2<125 2013 63 12576 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer