naa a22 4500 510807283 CHVBK 20180411083424.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s11548-012-0798-y doi (NATIONALLICENCE)springer-10.1007/s11548-012-0798-y Assessment of COPD severity by combining pulmonary function tests and chest CT images [Elektronische Daten] [Yukitaka Nimura, Takayuki Kitasaka, Hirotoshi Honma, Hirotsugu Takabatake, Masaki Mori, Hiroshi Natori, Kensaku Mori] Purpose Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitations. Physicians frequently assess the stage using pulmonary function tests and chest CT images. This paper describes a novel method to assess COPD severity by combining measurements of pulmonary function tests (PFT) and the results of chest CT image analysis. Methods The proposed method utilizes measurements from PFTs and chest CT scans to assess COPD severity. This method automatically classifies COPD severity into five stages, described in GOLD guidelines, by a multi-class AdaBoost classifier. The classifier utilizes 24 measurements as feature values, which include 18 measurements from PFTs and six measurements based on chest CT image analysis. A total of 3 normal and 46 abnormal (COPD) examinations performed in adults were evaluated using the proposed method to test its diagnostic capability. Results The experimental results revealed that its accuracy rates were 100.0% (resubstitution scheme) and 53.1% (leave-one-out scheme). A total of 95.7% of missed classifications were assigned in the neighboring severities. Conclusions These results demonstrate that the proposed method is a feasible means to assess COPD severity. A much larger sample size will be required to establish the limits of the method and provide clinical validation. CARS, 2012 Chronic obstructive pulmonary disease nationallicence Classification nationallicence AdaBoost nationallicence Pulmonary function tests nationallicence Image analysis nationallicence Lung nationallicence Nimura Yukitaka Information and Communications Headquarters, Nagoya University, Furo-cho, 464-8601, Chikusa-ku, Nagoya, Aichi, Japan aut Kitasaka Takayuki Faculty of Information Science, Aichi Institute of Technology, 1247, Yachigusa, Yakusa-cho, 470-0392, Toyota, Aichi, Japan aut Honma Hirotoshi Department of Respiratory Medicine, Sapporo-Kosei General Hospital, 8-5 Higashi, Kita-3-jo, 060-0033, Chuo-ku, Sapporo, Japan aut Takabatake Hirotsugu Department of Respiratory Medicine, Sapporo Minami-Sanjo Hospital, 6 Nishi, Minami-3-jo, 060-0063, Chuo-ku, Sapporo, Japan aut Mori Masaki Department of Respiratory Medicine, Sapporo-Kosei General Hospital, 8-5 Higashi, Kita-3-jo, 060-0033, Chuo-ku, Sapporo, Japan aut Natori Hiroshi Department of Respiratory Medicine, Keiwa-Kai Nishioka Hospital, 4-1-52, Nishioka-4-jo, 062-0034, Toyohira-ku, Sapporo, Japan aut Mori Kensaku Information and Communications Headquarters, Nagoya University, Furo-cho, 464-8601, Chikusa-ku, Nagoya, Aichi, Japan aut International Journal of Computer Assisted Radiology and Surgery Springer-Verlag 8/3(2013-05-01), 353-363 1861-6410 8:3<353 2013 8 11548 https://doi.org/10.1007/s11548-012-0798-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11548-012-0798-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nimura Yukitaka Information and Communications Headquarters, Nagoya University, Furo-cho, 464-8601, Chikusa-ku, Nagoya, Aichi, Japan aut NATIONALLICENCE 700 1- Kitasaka Takayuki Faculty of Information Science, Aichi Institute of Technology, 1247, Yachigusa, Yakusa-cho, 470-0392, Toyota, Aichi, Japan aut NATIONALLICENCE 700 1- Honma Hirotoshi Department of Respiratory Medicine, Sapporo-Kosei General Hospital, 8-5 Higashi, Kita-3-jo, 060-0033, Chuo-ku, Sapporo, Japan aut NATIONALLICENCE 700 1- Takabatake Hirotsugu Department of Respiratory Medicine, Sapporo Minami-Sanjo Hospital, 6 Nishi, Minami-3-jo, 060-0063, Chuo-ku, Sapporo, Japan aut NATIONALLICENCE 700 1- Mori Masaki Department of Respiratory Medicine, Sapporo-Kosei General Hospital, 8-5 Higashi, Kita-3-jo, 060-0033, Chuo-ku, Sapporo, Japan aut NATIONALLICENCE 700 1- Natori Hiroshi Department of Respiratory Medicine, Keiwa-Kai Nishioka Hospital, 4-1-52, Nishioka-4-jo, 062-0034, Toyohira-ku, Sapporo, Japan aut NATIONALLICENCE 700 1- Mori Kensaku Information and Communications Headquarters, Nagoya University, Furo-cho, 464-8601, Chikusa-ku, Nagoya, Aichi, Japan aut NATIONALLICENCE 773 0- International Journal of Computer Assisted Radiology and Surgery Springer-Verlag 8/3(2013-05-01), 353-363 1861-6410 8:3<353 2013 8 11548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer