naa a22 4500 510807925 CHVBK 20180411083426.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s11548-013-0840-8 doi (NATIONALLICENCE)springer-10.1007/s11548-013-0840-8 The Medical Imaging Interaction Toolkit: challenges and advances [Elektronische Daten] 10 years of open-source development [Marco Nolden, Sascha Zelzer, Alexander Seitel, Diana Wald, Michael Müller, Alfred Franz, Daniel Maleike, Markus Fangerau, Matthias Baumhauer, Lena Maier-Hein, Klaus Maier-Hein, Hans Meinzer, Ivo Wolf] Purpose: The Medical Imaging Interaction Toolkit (MITK) has been available as open-source software for almost 10 years now. In this period the requirements of software systems in the medical image processing domain have become increasingly complex. The aim of this paper is to show how MITK evolved into a software system that is able to cover all steps of a clinical workflow including data retrieval, image analysis, diagnosis, treatment planning, intervention support, and treatment control. Methods: MITK provides modularization and extensibility on different levels. In addition to the original toolkit, a module system, micro services for small, system-wide features, a service-oriented architecture based on the Open Services Gateway initiative (OSGi) standard, and an extensible and configurable application framework allow MITK to be used, extended and deployed as needed. A refined software process was implemented to deliver high-quality software, ease the fulfillment of regulatory requirements, and enable teamwork in mixed-competence teams. Results: MITK has been applied by a worldwide community and integrated into a variety of solutions, either at the toolkit level or as an application framework with custom extensions. The MITK Workbench has been released as a highly extensible and customizable end-user application. Optional support for tool tracking, image-guided therapy, diffusion imaging as well as various external packages (e.g. CTK, DCMTK, OpenCV, SOFA, Python) is available. MITK has also been used in several FDA/CE-certified applications, which demonstrates the high-quality software and rigorous development process. Conclusions: MITK provides a versatile platform with a high degree of modularization and interoperability and is well suited to meet the challenging tasks of today's and tomorrow's clinically motivated research. CARS, 2013 Open-source nationallicence Medical image analysis nationallicence Platform nationallicence Extensible nationallicence Service-oriented architecture nationallicence Software process nationallicence Quality management nationallicence Image-guided therapy nationallicence Nolden Marco Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Zelzer Sascha Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Seitel Alexander Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Wald Diana Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Müller Michael Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Franz Alfred Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Maleike Daniel Mint Medical GmbH, Friedrich-Ebert-Str. 2, 69221, Dossenheim, Heidelberg, Germany aut Fangerau Markus Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Baumhauer Matthias Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Maier-Hein Lena Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Maier-Hein Klaus Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Meinzer Hans Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Wolf Ivo Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163, Mannheim, Germany aut International Journal of Computer Assisted Radiology and Surgery Springer Berlin Heidelberg 8/4(2013-07-01), 607-620 1861-6410 8:4<607 2013 8 11548 https://doi.org/10.1007/s11548-013-0840-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11548-013-0840-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nolden Marco Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Zelzer Sascha Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Seitel Alexander Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Wald Diana Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Müller Michael Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Franz Alfred Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Maleike Daniel Mint Medical GmbH, Friedrich-Ebert-Str. 2, 69221, Dossenheim, Heidelberg, Germany aut NATIONALLICENCE 700 1- Fangerau Markus Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Baumhauer Matthias Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Maier-Hein Lena Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Maier-Hein Klaus Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Meinzer Hans Division of Medical and Biological Informatics (E130), German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Wolf Ivo Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163, Mannheim, Germany aut NATIONALLICENCE 773 0- International Journal of Computer Assisted Radiology and Surgery Springer Berlin Heidelberg 8/4(2013-07-01), 607-620 1861-6410 8:4<607 2013 8 11548 Metadata rights reserved Springer 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