naa a22 4500 510807984 CHVBK 20180411083427.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s11548-013-0820-z doi (NATIONALLICENCE)springer-10.1007/s11548-013-0820-z Comparative exploration of whole-body MR through locally rigid transforms [Elektronische Daten] [Oleh Dzyubachyk, Jorik Blaas, Charl Botha, Marius Staring, Monique Reijnierse, Johan Bloem, Rob van der Geest, Boudewijn Lelieveldt] PurposeWhole-body MRI is seeing increasing use in the study and diagnosis of disease progression. In this, a central task is the visual assessment of the progressive changes that occur between two whole-body MRI datasets, taken at baseline and follow-up. Current radiological workflow for this consists in manual search of each organ of interest on both scans, usually on multiple data channels, for further visual comparison. Large size of datasets, significant posture differences, and changes in patient anatomy turn manual matching in an extremely labor-intensive task that requires from radiologists high concentration for long period of time. This strongly limits the productivity and increases risk of underdiagnosis. Materials and methodsWe present a novel approach to the comparative visual analysis of whole-body MRI follow-up data. Our method is based on interactive derivation of locally rigid transforms from a pre-computed whole-body deformable registration. Using this approach, baseline and follow-up slices can be interactively matched with a single mouse click in the anatomical region of interest. In addition to the synchronized side-by-side baseline and matched follow-up slices, we have integrated four techniques to further facilitate the visual comparison of the two datasets: the "deformation sphere”, the color fusion view, the magic lens, and a set of uncertainty iso-contours around the current region of interest. ResultsWe have applied our method to the study of cancerous bone lesions over time in patients with Kahler's disease. During these studies, the radiologist carefully visually examines a large number of anatomical sites for changes. Our interactive locally rigid matching approach was found helpful in localization of cancerous lesions and visual assessment of changes between different scans. Furthermore, each of the features integrated in our software was separately evaluated by the experts. ConclusionWe demonstrated how our method significantly facilitates examination of whole-body MR datasets in follow-up studies by enabling the rapid interactive matching of regions of interest and by the explicit visualization of change. The Author(s), 2013 Whole-body imaging nationallicence MRI nationallicence Registration nationallicence Comparative visualization nationallicence Dzyubachyk Oleh Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut Blaas Jorik Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut Botha Charl Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut Staring Marius Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut Reijnierse Monique Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut Bloem Johan Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut van der Geest Rob Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut Lelieveldt Boudewijn Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut International Journal of Computer Assisted Radiology and Surgery Springer Berlin Heidelberg 8/4(2013-07-01), 635-647 1861-6410 8:4<635 2013 8 11548 https://doi.org/10.1007/s11548-013-0820-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11548-013-0820-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dzyubachyk Oleh Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Blaas Jorik Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Botha Charl Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Staring Marius Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Reijnierse Monique Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Bloem Johan Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- van der Geest Rob Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Lelieveldt Boudewijn Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 773 0- International Journal of Computer Assisted Radiology and Surgery Springer Berlin Heidelberg 8/4(2013-07-01), 635-647 1861-6410 8:4<635 2013 8 11548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer