naa a22 4500 510808077 CHVBK 20180411083427.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11548-012-0803-5 doi (NATIONALLICENCE)springer-10.1007/s11548-012-0803-5 Calibration of cone beam CT using relative attenuation ratio for quantitative assessment of bone density: a small animal study [Elektronische Daten] [Yifei Liu, Tobias Bäuerle, Leyun Pan, Antonia Dimitrakopoulou-Strauss, Ludwig Strauss, Christian Heiss, Reinhard Schnettler, Wolfhard Semmler, Liji Cao] PurposeCone beam computed tomography (CBCT) has the disadvantage of providing non-quantitative results for bone density determination. The aim of this study is to calibrate CBCT results by using an internal reference (such as muscle) for quantitatively assessing bone density. Methods We developed a new method using the relative attenuation ratio between two nearby materials (such as bone and muscle) for systemic error correction in CBCT that depends on the relative object position in the image volume. Phantom calibration was performed to calculate the acquired attenuation ratio in Hounsfield units (HU), comparable to the results from clinical multislice spiral computed tomography (MSCT). In addition, a small animal study with an osteoporotic rat model was evaluated to show the feasibility of this presented method to quantitatively assess bone density using a CBCT system. Results The phantom study results showed that the calibration process successfully corrected the systemic inaccuracy from CBCT, and the calibrated HU values agreed with the values measured from MSCT. In the small animal study, the quantitative bone densities assessed from the calibrated CBCT results were consistent with the results from MSCT data. Conclusion A practical method to quantitatively estimate attenuation (HU) values for bone tissues from CBCT scans that are comparable to MSCT scans is proposed. The method may improve the quantification ability of CBCT scanning without any additional hardware requirements. CARS, 2012 Cone beam CT nationallicence Hounsfield unit nationallicence Quantification nationallicence Calibration nationallicence Liu Yifei Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Bäuerle Tobias Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Pan Leyun Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany aut Dimitrakopoulou-Strauss Antonia Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany aut Strauss Ludwig Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany aut Heiss Christian Department of Trauma Surgery, Justus-Liebig-University, Giessen, Germany aut Schnettler Reinhard Department of Trauma Surgery, Justus-Liebig-University, Giessen, Germany aut Semmler Wolfhard Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Cao Liji Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut International Journal of Computer Assisted Radiology and Surgery Springer Berlin Heidelberg 8/5(2013-09-01), 733-739 1861-6410 8:5<733 2013 8 11548 https://doi.org/10.1007/s11548-012-0803-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11548-012-0803-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Yifei Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Bäuerle Tobias Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Pan Leyun Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Dimitrakopoulou-Strauss Antonia Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Strauss Ludwig Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Heiss Christian Department of Trauma Surgery, Justus-Liebig-University, Giessen, Germany aut NATIONALLICENCE 700 1- Schnettler Reinhard Department of Trauma Surgery, Justus-Liebig-University, Giessen, Germany aut NATIONALLICENCE 700 1- Semmler Wolfhard Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Cao Liji Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 773 0- International Journal of Computer Assisted Radiology and Surgery Springer Berlin Heidelberg 8/5(2013-09-01), 733-739 1861-6410 8:5<733 2013 8 11548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer