naa a22 4500 510808166 CHVBK 20180411083428.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11548-012-0801-7 doi (NATIONALLICENCE)springer-10.1007/s11548-012-0801-7 An in vivo subject-specific 3D functional knee joint model using combined MR imaging [Elektronische Daten] [Bailiang Chen, Tryphon Lambrou, Amaka Offiah, Pedro Gondim Teixeira, Martin Fry, Andrew Todd-Pokropek] Purpose: We aim to quantitatively characterise the knee joint function in vivo under body-weight-bearing conditions via subject-specific models extracted from magnetic resonance (MR) data, in order to better understand the knee joint kinematic function in 3D. Methods: Six healthy volunteers without any record of knee abnormality were scanned using a combined MR imaging strategy to record quasi-squatting motion and 3D knee anatomy. After a semi-automatic segmentation to delineate tibio-femoral articulation components, motion data were mapped to the anatomical data using a bi-rigid registration in order to achieve six degrees of freedom. The individual knee joint function was characterised by analysing the tibio-femoral articulation contact mechanism based on the reconstructed models in 3D and MR images in 2D. Contact points were extracted and their trajectory was plotted on the tibia plateau. Results: The 3D models clearly show the relative rotation and gliding between tibia and femur during global flexion. Within the measured flexion arc, the contact points move less between 30 $$^{\circ }$$ and 100 $$^{\circ }$$ on both tibial plateaux as compared to that on the rest of the flexion arc. Four out of the six volunteers showed a global pattern of less moving extent of contact points on the medial tibial plateau than on the lateral tibial plateau in both 3D and 2D. Conclusion: The proposed subject-specific model is able to characterise knee joint kinematic function. It provides a way to describe knee joint surface kinematics quantitatively, which may help to better understand the knee function and joint derangements. CARS, 2012 MRI nationallicence Surface kinematics nationallicence Body-weight bearing nationallicence Subject-specific knee joint model nationallicence Contact mechanism nationallicence Chen Bailiang Pôle Imagerie, CHU de Nancy, Nancy, France aut Lambrou Tryphon Lincoln School of Computer Science, University of Lincoln, Lincoln, UK aut Offiah Amaka Academic Unit of Child Health, University of Sheffield, Sheffield, UK aut Gondim Teixeira Pedro Service d'Imagerie Guilloz, CHU de Nancy, Nancy, France aut Fry Martin Department of Medical Physics and Bioengineering, University College London, Gower Street, WC1E 6BT, London, UK aut Todd-Pokropek Andrew Department of Medical Physics and Bioengineering, University College London, Gower Street, WC1E 6BT, London, UK aut International Journal of Computer Assisted Radiology and Surgery Springer Berlin Heidelberg 8/5(2013-09-01), 741-750 1861-6410 8:5<741 2013 8 11548 https://doi.org/10.1007/s11548-012-0801-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11548-012-0801-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Bailiang Pôle Imagerie, CHU de Nancy, Nancy, France aut NATIONALLICENCE 700 1- Lambrou Tryphon Lincoln School of Computer Science, University of Lincoln, Lincoln, UK aut NATIONALLICENCE 700 1- Offiah Amaka Academic Unit of Child Health, University of Sheffield, Sheffield, UK aut NATIONALLICENCE 700 1- Gondim Teixeira Pedro Service d'Imagerie Guilloz, CHU de Nancy, Nancy, France aut NATIONALLICENCE 700 1- Fry Martin Department of Medical Physics and Bioengineering, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Todd-Pokropek Andrew Department of Medical Physics and Bioengineering, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 773 0- International Journal of Computer Assisted Radiology and Surgery Springer Berlin Heidelberg 8/5(2013-09-01), 741-750 1861-6410 8:5<741 2013 8 11548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer