naa a22 4500 510808352 CHVBK 20180411083429.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11548-012-0749-7 doi (NATIONALLICENCE)springer-10.1007/s11548-012-0749-7 Independent prognostic value of whole-body metabolic tumor burden from FDG-PET in non-small cell lung cancer [Elektronische Daten] [Hao Zhang, Kristen Wroblewski, Daniel Appelbaum, Yonglin Pu] Purpose: To determine whether whole-body metabolic tumor burden, measured as either metabolic tumor volume (MTVWB) or total lesion glycolysis (TLGWB), using FDG-PET/CT is an independent prognostic marker in non-small cell lung cancer (NSCLC). Methods: 328 patients with histologically proven NSCLC were identified for this retrospective analysis. This study was approved by our Institutional Review Board. All patients underwent baseline 18F-FDG-PET/CT scan imaging before therapy. The MTVWB, TLGWB, maximum standardized uptake value (SUVmaxWB) and mean standardized uptake value (SUVmeanWB) of tumors throughout the whole body were measured from FDG-PET images with semi-automated 3D contouring software. Results: In univariate analysis, there was a statistically significant association of overall survival (OS) with the MTVWB (hazard ratio (HR) = 1.62, p<0.001), TLGWB (HR = 1.47, p<0.001). The patients with a MTVWB≤ median of 65.7ml and TLGWB≤ median of 205.11 SUVmean * ml had a median OS of 41.1 and 35.4months compared with 9.5 and 9.7months for those with a MTVWB >65.7ml and TLGWB>205.11SUVmean * ml, respectively. From a series of multivariate Cox regression models, the MTVWB and TLGWB were significantly better than SUVmaxWB and SUVmeanWB at prognostication and significantly associated with patients' OS with HRs of 1.50 (p<0.001) and 1.42 (p<0.001), respectively, after adjustment for patient's age, gender and treatment intent as well as the tumor SUVmaxWB, histology and stage. Conclusions: MTVWB and TLGWB as metabolic tumor burden measurements in 18F-FDG-PET/CT are independent prognostic markers and are significantly better than SUVmaxWB and SUVmeanWB at prognostication. CARS, 2012 Non-small cell lung cancer nationallicence Tumor burden nationallicence F-18 Fluorodeoxyglucose (FDG) nationallicence Positron emission tomography (PET) nationallicence Zhang Hao Department of Radiology, First Hospital of Lanzhou University, 730000, Lanzhou, Gansu, China aut Wroblewski Kristen Department of Health Studies, The University of Chicago, 60637, Chicago, IL, USA aut Appelbaum Daniel Department of Radiology, University of Chicago, MC 2026, 60637, Chicago, IL, USA aut Pu Yonglin Department of Radiology, University of Chicago, MC 2026, 60637, Chicago, IL, USA aut International Journal of Computer Assisted Radiology and Surgery Springer-Verlag 8/2(2013-03-01), 181-191 1861-6410 8:2<181 2013 8 11548 https://doi.org/10.1007/s11548-012-0749-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11548-012-0749-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Hao Department of Radiology, First Hospital of Lanzhou University, 730000, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Wroblewski Kristen Department of Health Studies, The University of Chicago, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Appelbaum Daniel Department of Radiology, University of Chicago, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Pu Yonglin Department of Radiology, University of Chicago, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 773 0- International Journal of Computer Assisted Radiology and Surgery Springer-Verlag 8/2(2013-03-01), 181-191 1861-6410 8:2<181 2013 8 11548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer