naa a22 4500 510813534 CHVBK 20180411083453.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12328-012-0346-x doi (NATIONALLICENCE)springer-10.1007/s12328-012-0346-x Noninvasive evaluation of mucosal healing in inflammatory bowel diseases [Elektronische Daten] [Jun Kato, Sakiko Hiraoka, Asuka Nakarai, Masao Ichinose] Current opinions increasingly cite the need to achieve not only clinical response but also endoscopic mucosal healing in the treatment of both types of inflammatory bowel disease: ulcerative colitis (UC) and Crohn's disease (CD). Although endoscopic procedures are necessary for confirmation of mucosal healing, undergoing colonoscopy is invasive and burdensome to patients. Therefore, alternative noninvasive methods of evaluating or predicting mucosal status have been eagerly desired. For this purpose, blood, fecal, and radiologic modalities have been suggested and examined. C-reactive protein and fecal markers such as fecal calprotectin can evaluate active inflammation to some extent in both UC and CD. However, their predictive values for mucosal healing have not yet been fully evaluated and current knowledge indicates that the values were rather insufficient. Radiologic modalities such as computed tomography, magnetic resonance, and ultrasound can also evaluate mucosal inflammation but are currently not suitable for detection of healing. Capsule endoscopy may be optimal for evaluating mucosal status of the small bowel in CD patients, but sufficient data are not yet available, particularly for mucosal healing. Thus, these candidates for the surrogate modality are currently imperfect for evaluation of mucosal healing, but the changes in values/findings of these modalities after initiation of therapy appear to be rather promising as a marker of efficacy of the therapy. Finally, our recent data showed that a fecal immunochemical test for evaluation of mucosal healing in UC was very promising and this method should be further evaluated in CD also. Springer Japan, 2012 Ulcerative colitis nationallicence Crohn's disease nationallicence Endoscopy nationallicence C-reactive protein nationallicence Fecal immunochemical test nationallicence Kato Jun Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, 641-0012, Wakayama, Wakayama, Japan aut Hiraoka Sakiko Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut Nakarai Asuka Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut Ichinose Masao Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, 641-0012, Wakayama, Wakayama, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/1(2013-02-01), 1-7 1865-7257 6:1<1 2013 6 12328 https://doi.org/10.1007/s12328-012-0346-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-012-0346-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kato Jun Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, 641-0012, Wakayama, Wakayama, Japan aut NATIONALLICENCE 700 1- Hiraoka Sakiko Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut NATIONALLICENCE 700 1- Nakarai Asuka Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut NATIONALLICENCE 700 1- Ichinose Masao Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, 641-0012, Wakayama, Wakayama, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/1(2013-02-01), 1-7 1865-7257 6:1<1 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer