naa a22 4500 510813585 CHVBK 20180411083454.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12328-012-0343-0 doi (NATIONALLICENCE)springer-10.1007/s12328-012-0343-0 Giant cavernous hepatic hemangioma shrunk by use of sorafenib [Elektronische Daten] [Satoyoshi Yamashita, Kohsuke Okita, Katsunori Harada, Atsuyoshi Hirano, Teruaki Kimura, Akira Kato, Kiwamu Okita] Here we report a case of a 76-year-old man with a giant cavernous hepatic hemangioma of more than 20cm in diameter. Since the hepatic hemangioma was actually growing and might possibly rupture and he complained of abdominal symptoms, we decided to perform interventional therapy. First we performed transcatheter arterial embolization (TAE) of the hepatic arteries. However, since this was not sufficiently effective, we added sorafenib (600mg/day). As a result, the tumor shrank with symptomatic improvement. Subsequently, an adverse event occurred, and we suspended the sorafenib therapy. Then, the tumor began to grow, and we resumed administering sorafenib at 400mg/day. The tumor shrank again, and we continued the sorafenib therapy thereafter. The tumor shrinkage, although possibly induced by the effect of TAE, is considered primarily due to the effect of treatment with sorafenib, because (1) TAE did not sufficiently reduce the blood supply to the inside of the tumor; (2) other tumors shrank in the area not targeted by TAE; and (3) the tumor grew during suspension of sorafenib therapy and shrank again after resuming the treatment. The Author(s), 2012 Hepatic hemangioma nationallicence Sorafenib nationallicence Transcatheter arterial embolization nationallicence Yamashita Satoyoshi Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut Okita Kohsuke Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut Harada Katsunori Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut Hirano Atsuyoshi Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut Kimura Teruaki Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut Kato Akira Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut Okita Kiwamu Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/1(2013-02-01), 55-62 1865-7257 6:1<55 2013 6 12328 https://doi.org/10.1007/s12328-012-0343-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-012-0343-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamashita Satoyoshi Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Okita Kohsuke Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Harada Katsunori Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Hirano Atsuyoshi Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Kimura Teruaki Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Kato Akira Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Okita Kiwamu Department of Gastroenterology, Social Insurance Shimonoseki Welfare Hospital, 3-3-8 Kami-Shinchi, 750-0061, Shimonoseki, Yamaguchi, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/1(2013-02-01), 55-62 1865-7257 6:1<55 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer