naa a22 4500 510813666 CHVBK 20180411083454.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12328-013-0421-y doi (NATIONALLICENCE)springer-10.1007/s12328-013-0421-y A rapidly progressive and fatal case of nonalcoholic steatohepatitis following pancreaticoduodenectomy [Elektronische Daten] [Hideaki Miura, Masayoshi Ijichi, Yoshitaka Ando, Korenobu Hayama, Kuniko IIhara, Haruki Yamada, Yasutsugu Bandai] Nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) usually occurs in patients with metabolic syndrome. However, it can develop in relation with pancreaticoduodenectomy (PD) independent of insulin resistance. NAFLD/NASH potentially progresses to liver cirrhosis and subsequent end-stage liver disease, but in general the disease progression is very slow. We here report the case of a 57-year-old Japanese woman who underwent PD for pancreatic head cancer, subsequent to which she developed rapidly progressive NASH without prior liver diseases, resulting in death due to hepatic failure 5months after PD. Marked body weight loss was a distinguishing clinical feature. Severe malnutrition induced by pancreatic exocrine insufficiency, postoperative eating disorder and exacerbation of diabetes mellitus were thought to be etiologically associated with the rapid progression of her disease. This case suggests the necessity of close hepatic surveillance as well as nutritional evaluation followed by prophylactic pancreatic enzyme replacement and nutritional supply after PD. Springer Japan, 2013 Nonalcoholic fatty liver disease (NAFLD) nationallicence Nonalcoholic steatohepatitis (NASH) nationallicence Diabetes mellitus (DM) nationallicence Pancreatic cancer nationallicence Pancreaticoduodenectomy (PD) nationallicence Pancreatic exocrine deficiency nationallicence Miura Hideaki Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut Ijichi Masayoshi Department of Surgery, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut Ando Yoshitaka Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut Hayama Korenobu Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut IIhara Kuniko Department of Pathology, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut Yamada Haruki Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut Bandai Yasutsugu Department of Surgery, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/6(2013-12-01), 470-475 1865-7257 6:6<470 2013 6 12328 https://doi.org/10.1007/s12328-013-0421-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0421-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miura Hideaki Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut NATIONALLICENCE 700 1- Ijichi Masayoshi Department of Surgery, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut NATIONALLICENCE 700 1- Ando Yoshitaka Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut NATIONALLICENCE 700 1- Hayama Korenobu Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut NATIONALLICENCE 700 1- IIhara Kuniko Department of Pathology, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamada Haruki Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut NATIONALLICENCE 700 1- Bandai Yasutsugu Department of Surgery, Social Insurance Central General Hospital, 3-22-1 Hyakunin-cho, Shinjuku-ku, 169-0073, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/6(2013-12-01), 470-475 1865-7257 6:6<470 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer